Gene Symbol | PNPLA8 |
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Entrez Gene | 50640 |
Alt Symbol | IPLA2(GAMMA), IPLA2-2, IPLA2G, iPLA2gamma |
Species | Human |
Gene Type | protein-coding |
Description | patatin-like phospholipase domain containing 8 |
Other Description | PNPLA-gamma|calcium-independent phospholipase A2-gamma|iPLA2 gamma|iPLA2-gamma|intracellular membrane-associated calcium-independent phospholipase A2 gamma|membrane-associated calcium-independent phospholipase A2 gamma|patatin-like phospholipase domain-containing protein 8 |
Swissprots | Q8N3I3 Q9NUN2 O95035 Q9NR17 Q9H7T5 A4D0S1 C9JZI4 Q9NZ79 Q9NP80 |
Accessions | AAD08847 EAL24384 EAL24385 EAW83432 EAW83433 EAW83434 EAW83435 Q9NP80 AB041261 BAA94997 AF217519 AAF67630 AF263613 AAF75269 AF263947 AAF81246 AK002115 BAA92090 AK024335 BAB14890 AK291755 BAF84444 AL834147 CAD38859 AM392663 CAL37541 BC005203 BC032999 AAH32999 BX647865 DQ890948 ABM81874 DQ894111 ABM85037 XM_005250396 XP_005250453 XM_011516274 XP_011514576 XM_011516275 XP_011514577 XR_927471 XR_927472 XR_927473 NM_001256007 NP_001242936 NM_001256008 NP_001242937 NM_001256009 NP_001242938 NM_001256010 NP_001242939 NM_001256011 NP_001242940 NM_015723 NP_056538 |
Function | Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. {ECO:0000269|PubMed:10744668, ECO:0000269|PubMed:15695510}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. |
Tissue Specificity | Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart. {ECO:0000269|PubMed:10744668, ECO:0000269|PubMed:10833412, ECO:0000269|PubMed:15629460, ECO:0000269|PubMed:15695510}. |
iPLA 2 γ (S-14) - sc-241492 from Santa Cruz Biotechnology
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iPLA 2 γ (E-14) - sc-241491 from Santa Cruz Biotechnology
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Anti-PNPLA8 antibody - ab140151 from Abcam
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Anti-PNPLA8 antibody - ab154233 from Abcam
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Anti-PNPLA8 antibody - ab74242 from Abcam
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Anti-PNPLA8 antibody - ab98844 from Abcam
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Anti-PNPLA8 Antibody (aa212-240, APC) - LS-C223686 from LifeSpan Bioscience
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Anti-PNPLA8 Antibody (aa212-240, AP) - LS-C223684 from LifeSpan Bioscience
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Anti-PNPLA8 Antibody (aa212-240, Biotin) - LS-C223687 from LifeSpan Bioscience
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Anti-PNPLA8 Antibody (aa212-240, FITC) - LS-C223688 from LifeSpan Bioscience
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Anti-PNPLA8 Antibody (aa212-240, Azide-free, HRP) - LS-C223689 from LifeSpan Bioscience
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Anti-PNPLA8 Antibody (aa219-248) - LS-C324145 from LifeSpan Bioscience
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Anti-PNPLA8 Antibody (aa212-240, PE) - LS-C223690 from LifeSpan Bioscience
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Anti-PNPLA8 Antibody (aa691-740) - LS-C119797 from LifeSpan Bioscience
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Anti-PNPLA8 Antibody (aa359-408) - LS-C107856 from LifeSpan Bioscience
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Anti-PNPLA8 Antibody (aa212-240) - LS-C163828 from LifeSpan Bioscience
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Anti-PNPLA8 Antibody (aa129-358) - LS-C179091 from LifeSpan Bioscience
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PNPLA8 Antibody - NBP1-83098 from Novus Biologicals
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PNPLA8 Antibody - NBP1-54326 from Novus Biologicals
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PNPLA8 Antibody - NBP2-19879 from Novus Biologicals
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Anti-PNPLA8 antibody produced in rabbit - HPA020083 from Sigma-Aldrich
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Anti-PNPLA8, C-Terminal antibody produced in rabbit - SAB4502074 from Sigma-Aldrich
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Anti-PNPLA8 antibody produced in rabbit - SAB2105053 from Sigma-Aldrich
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ANTI-PNPLA8(N-TERMINAL) antibody produced in rabbit - SAB1306959 from Sigma-Aldrich
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PNPLA8 antibody - middle region (ARP56759_P050) - ARP56759_P050 from Aviva Systems Biology
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