RGS20
| Gene Symbol | RGS20 |
|---|---|
| Entrez Gene | 8601 |
| Alt Symbol | RGSZ1, ZGAP1, g(z)GAP, gz-GAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | regulator of G-protein signaling 20 |
| Other Description | gz-selective GTPase-activating protein|regulator of G-protein signaling 20 variant 2|regulator of G-protein signaling Z1|regulator of G-protein signalling 20|regulator of Gz-selective protein signaling 1 |
| Swissprots | Q96BG9 O76081 |
| Accessions | EAW86734 EAW86735 EAW86736 EAW86737 EAW86738 O76081 AF060877 AAC62009 AF074979 AAC62013 AF366054 AAK54122 AF366055 AAK54123 AF366056 AAK54124 AF366057 AAK54125 AF493940 AAM12654 AK094503 BAG52876 AY046538 AAL03971 BC015614 AAH15614 BC018618 BC031328 BC054867 BC063490 AAH63490 HQ257937 ADR82691 JQ308180 AFF59490 XM_011517622 XP_011515924 NM_001286673 NP_001273602 NM_001286674 NP_001273603 NM_001286675 NP_001273604 NM_003702 NP_003693 NM_170587 NP_733466 NR_104578 NR_104579 |
| Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation. {ECO:0000250}. |
| Tissue Specificity | Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe. |
RGS20 CRISPR/Cas9 KO Plasmid (h) - sc-409202 from Santa Cruz Biotechnology
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RGS20 HDR Plasmid (h) - sc-409202-HDR from Santa Cruz Biotechnology
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RGS20 Double Nickase Plasmid (h) - sc-409202-NIC from Santa Cruz Biotechnology
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RGS20 Double Nickase Plasmid (h2) - sc-409202-NIC-2 from Santa Cruz Biotechnology
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RGS20 CRISPR Activation Plasmid (h) - sc-409202-ACT from Santa Cruz Biotechnology
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RGS20 CRISPR Activation Plasmid (h2) - sc-409202-ACT-2 from Santa Cruz Biotechnology
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RGS20 Lentiviral Activation Particles (h) - sc-409202-LAC from Santa Cruz Biotechnology
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RGS20 Lentiviral Activation Particles (h2) - sc-409202-LAC-2 from Santa Cruz Biotechnology
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RGS20 siRNA (h) - sc-61470 from Santa Cruz Biotechnology
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RGS20 shRNA Plasmid (h) - sc-61470-SH from Santa Cruz Biotechnology
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RGS20 shRNA (h) Lentiviral Particles - sc-61470-V from Santa Cruz Biotechnology
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RGS20 RNAi - H00008601-R02 from Novus Biologicals
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RGS20 RNAi - H00008601-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN18225 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18225 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06758 from Sigma-Aldrich
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RGS20 siRNA (Human) - CRH5649 from Cohesion Biosciences
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RGS20 - MBS8213110 from MyBioSource
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shRNA set against Human RGS20 (NM_003702.3) - SHH394936 from Creative biogene
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RGS20 shRNA Plasmid (Human) - CHH5649 from Cohesion Biosciences
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RGS20 miRNA 3'UTR clone - MiUTR3H-09034 from Creative biogene
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RGS20 miRNA 3'UTR clone - MiUTR3H-09035 from Creative biogene
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