| Gene Symbol |
TRPC5
|
| Entrez Gene |
7224
|
| Alt Symbol |
PPP1R159, TRP5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily C, member 5
|
| Other Description |
TRP-5|hTRP5|protein phosphatase 1, regulatory subunit 159|short transient receptor potential channel 5|transient receptor potential channel 5|transient receptor protein 5
|
| Swissprots |
O75233 Q9Y514 B2RP53 Q5JXY8 Q9UL62
|
| Accessions |
AAC24563 EAX02630 Q9UL62 AB209258 BAD92495 AF054568 AAF00002 BC137271 AAI37272 BC137274 AAI37275 NM_012471 NP_036603
|
| Function |
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. {ECO:0000250, ECO:0000269|PubMed:16284075}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16284075}; Multi-pass membrane protein {ECO:0000269|PubMed:16284075}.
|
| Tissue Specificity |
Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. {ECO:0000269|PubMed:9687496}.
|
![Western Blot: TRPC5 Overexpression Lysate (Adult Normal) [NBL1-17334] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TRPC5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8088_TRPC5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17334-img0002.jpg)