Gene Symbol | TRPC5 |
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Entrez Gene | 7224 |
Alt Symbol | PPP1R159, TRP5 |
Species | Human |
Gene Type | protein-coding |
Description | transient receptor potential cation channel, subfamily C, member 5 |
Other Description | TRP-5|hTRP5|protein phosphatase 1, regulatory subunit 159|short transient receptor potential channel 5|transient receptor potential channel 5|transient receptor protein 5 |
Swissprots | O75233 Q9Y514 B2RP53 Q5JXY8 Q9UL62 |
Accessions | AAC24563 EAX02630 Q9UL62 AB209258 BAD92495 AF054568 AAF00002 BC137271 AAI37272 BC137274 AAI37275 NM_012471 NP_036603 |
Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. {ECO:0000250, ECO:0000269|PubMed:16284075}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:16284075}; Multi-pass membrane protein {ECO:0000269|PubMed:16284075}. |
Tissue Specificity | Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. {ECO:0000269|PubMed:9687496}. |
TRPC5 CRISPR/Cas9 KO Plasmid (h) - sc-403745 from Santa Cruz Biotechnology
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TRPC5 HDR Plasmid (h) - sc-403745-HDR from Santa Cruz Biotechnology
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TRPC5 Double Nickase Plasmid (h) - sc-403745-NIC from Santa Cruz Biotechnology
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TRPC5 Double Nickase Plasmid (h2) - sc-403745-NIC-2 from Santa Cruz Biotechnology
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TRPC5 CRISPR Activation Plasmid (h) - sc-403745-ACT from Santa Cruz Biotechnology
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TRPC5 CRISPR Activation Plasmid (h2) - sc-403745-ACT-2 from Santa Cruz Biotechnology
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TRPC5 Lentiviral Activation Particles (h) - sc-403745-LAC from Santa Cruz Biotechnology
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TRPC5 Lentiviral Activation Particles (h2) - sc-403745-LAC-2 from Santa Cruz Biotechnology
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TRPC5 siRNA (h) - sc-42670 from Santa Cruz Biotechnology
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TRPC5 shRNA Plasmid (h) - sc-42670-SH from Santa Cruz Biotechnology
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TRPC5 shRNA (h) Lentiviral Particles - sc-42670-V from Santa Cruz Biotechnology
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TRPC5 RNAi - H00007224-R01 from Novus Biologicals
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MISSION® esiRNA - EHU039341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2382 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2382 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13206 from Sigma-Aldrich
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TRPC5 siRNA (Human) - CRH4948 from Cohesion Biosciences
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TRPC5 - MBS8235245 from MyBioSource
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shRNA set against Human Trpc5 (NM_012471.2) - SHH435584 from Creative biogene
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shRNA set against Human TRPC5(NM_012471.2) - SHL096960 from Creative biogene
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TRPC5 shRNA Plasmid (Human) - CHH4948 from Cohesion Biosciences
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TRPC5 miRNA 3'UTR clone - MiUTR1H-10784 from Creative biogene
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