SAV1

Gene Symbol SAV1
Entrez Gene 60485
Alt Symbol SAV, WW45, WWP4
Species Human
Gene Type protein-coding
Description salvador family WW domain containing protein 1
Other Description 1700040G09Rik|45 kDa WW domain protein|WW domain-containing adaptor 45|hWW45|protein salvador homolog 1|salvador homolog 1
Swissprots Q6IA58 Q9H4B6 A8K4B8 D3DSB6 Q9HAK9 Q9H949
Accessions EAW65702 EAW65703 EAW65704 Q9H4B6 AF088000 AJ292969 CAC13972 AK021500 BAB13835 AK023071 BAB14390 AK095903 BAG53163 AK225896 AK290883 BAF83572 AL833378 BC006385 BC020537 AAH20537 CR457297 CAG33578 DA479812 DA536352 DB543756 HQ447308 ADQ31795 XM_011537057 XP_011535359 XM_011537058 XP_011535360 NM_021818 NP_068590
Function Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the tra
Subcellular Location Nucleus {ECO:0000269|PubMed:19212654}. Cytoplasm {ECO:0000269|PubMed:19212654}.
Tissue Specificity Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines. {ECO:0000269|PubMed:19212654}.
Top Pathways Hippo signaling pathway

SAV1 (D6M6X) Rabbit mAb - 13301 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6M6X
Western blot analysis of extracts from various cell lines using SAV1 (D6M6X) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Sav1 Antibody - 3507 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using Sav1 Antibody.

SAV1 (F-5) - sc-374366 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SAV1 (F-5): sc-374366. Western blot analysis of SAV1 expression in non-transfected: sc-117752 (A) and human SAV1 transfected: sc-113437 (B) 293T whole cell lysates.

SAV1 (T-16) - sc-165428 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SAV1 (H-200) - sc-135394 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SAV1 (H-200): sc-135394. Western blot analysis of SAV1 expression in non-transfected: sc-117752 (A) and mouse SAV1 transfected: sc-123362 (B) 293T whole cell lysates.

SAV1 (JJ-6) - sc-101205 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SAV1 (JJ-6): sc-101205. Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing nuclear and cytoplasmic localization.

Anti-SAV1 antibody - ab105105 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SAV1 antibody (ab105105) at 1 µg/mlLane 1 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lane 2 : Heart (Human) Whole Cell Lysate - fetal normal tissueLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SAV1 antibody - ab172705 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SAV1 antibody (ab172705) at 1 µg/mlLane 1 : SAV1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-mouse HRP at 1/2500 dilution

Anti-SAV1 antibody - ab172724 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SAV1 antibody (ab172724) at 1 µg/mlLane 1 : SAV1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-SAV1 antibody - ab57534 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SAV1 antibody - N-terminal - ab189553 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-SAV1 antibody - N-terminal (ab189553) at 1/1000 dilutionLane 1 : HeLa cell extractLane 2 : mouse thymus extract

Anti-SAV1 / WW45 Antibody (aa254-266) - LS-C87224 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SAV1 / WW45 Antibody (aa64-92, AP) - LS-C223984 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAV1 / WW45 Antibody (aa64-92, Biotin) - LS-C223987 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAV1 / WW45 Antibody (aa64-92, PE) - LS-C223991 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAV1 / WW45 Antibody (aa64-92, Azide-free, HRP) - LS-C223989 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAV1 / WW45 Antibody (aa64-92, FITC) - LS-C223988 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAV1 / WW45 Antibody (aa64-92) - LS-C324919 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAV1 / WW45 Antibody (aa167-383, clone 2B7) - LS-C339313 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B7
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SAV1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SAV1.

Anti-SAV1 / WW45 Antibody (aa167-383, clone 7C7) - LS-C339402 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7C7
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SAV1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SAV1.

Anti-SAV1 / WW45 Antibody (clone 3A10) - LS-C139346 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A10
SAV1 monoclonal antibody (M04), clone 3A10. Western blot of SAV1 expression in HeLa NE.

Anti-SAV1 / WW45 Antibody (aa65-92) IHC-plus™ - LS-B10422 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-SAV1 / WW45 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10422 dilution 1:100.

Anti-SAV1 / WW45 Antibody (aa266-315) IHC-plus™ - LS-B11139 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-SAV1 / WW45 Antibody (aa64-92, APC) - LS-C223985 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

SAV1 Antibody (3B2) - H00060485-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B2
Western Blot: SAV1 Antibody (3B2) [H00060485-M02] - SAV1 monoclonal antibody (M02), clone 3B2. Analysis of SAV1 expression in HepG2.
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