| Gene Symbol | SAV1 |
|---|---|
| Entrez Gene | 60485 |
| Alt Symbol | SAV, WW45, WWP4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | salvador family WW domain containing protein 1 |
| Other Description | 1700040G09Rik|45 kDa WW domain protein|WW domain-containing adaptor 45|hWW45|protein salvador homolog 1|salvador homolog 1 |
| Swissprots | Q6IA58 Q9H4B6 A8K4B8 D3DSB6 Q9HAK9 Q9H949 |
| Accessions | EAW65702 EAW65703 EAW65704 Q9H4B6 AF088000 AJ292969 CAC13972 AK021500 BAB13835 AK023071 BAB14390 AK095903 BAG53163 AK225896 AK290883 BAF83572 AL833378 BC006385 BC020537 AAH20537 CR457297 CAG33578 DA479812 DA536352 DB543756 HQ447308 ADQ31795 XM_011537057 XP_011535359 XM_011537058 XP_011535360 NM_021818 NP_068590 |
| Function | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the tra |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:19212654}. Cytoplasm {ECO:0000269|PubMed:19212654}. |
| Tissue Specificity | Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines. {ECO:0000269|PubMed:19212654}. |
| Top Pathways | Hippo signaling pathway |