| Gene Symbol | DYRK2 |
|---|---|
| Entrez Gene | 8445 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
| Other Description | dual specificity tyrosine-phosphorylation-regulated kinase 2 |
| Swissprots | B2R9V9 Q9BRB5 Q92630 |
| Accessions | CCQ43222 EAW97176 EAW97177 Q92630 AK024870 AK025018 AK313937 BAG36656 BC005809 AAH05809 BC006375 AAH06375 CN303286 DA768075 DB461362 JF432719 ADZ15936 Y09216 CAA70418 Y13493 CAA73885 NM_003583 NP_003574 NM_006482 NP_006473 |
| Function | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser- 641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required |
| Subcellular Location | Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage. |
| Tissue Specificity | Testis, after the onset of spermatogenesis. {ECO:0000269|PubMed:9748265}. |