DYRK2

Gene Symbol	DYRK2
Entrez Gene	8445
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Other Description	dual specificity tyrosine-phosphorylation-regulated kinase 2
Swissprots	B2R9V9 Q9BRB5 Q92630
Accessions	CCQ43222 EAW97176 EAW97177 Q92630 AK024870 AK025018 AK313937 BAG36656 BC005809 AAH05809 BC006375 AAH06375 CN303286 DA768075 DB461362 JF432719 ADZ15936 Y09216 CAA70418 Y13493 CAA73885 NM_003583 NP_003574 NM_006482 NP_006473
Function	Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser- 641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required
Subcellular Location	Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.
Tissue Specificity	Testis, after the onset of spermatogenesis. {ECO:0000269|PubMed:9748265}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human DYRK2 full length protein - ab133138 from Abcam Category Protein Prices $352.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human DYRK2 full length protein - ab152869 from Abcam Category Protein Prices $410.00 Sizes 10 µg Source Wheat germ Species Human

Human DYRK2 full length protein - ab79734 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human DYRK2 protein fragment - ab152870 from Abcam Category Protein Source Wheat germ Species Human

DYRK2 Antibody Blocking Peptide - LS-E2945 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DYRK2 Antibody Blocking Peptide - LS-E23448 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DYRK2 Antibody Blocking Peptide - LS-E9031 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DYRK2 Antibody Blocking Peptide - LS-E23449 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DYRK2 Antibody Blocking Peptide - LS-E31103 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human DYRK2 Protein - H00008445-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human DYRK2 Protein - H00008445-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DYRK2 Blocking Peptide - NBP1-76560PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

DYRK2 Peptide - P2541 from Novus Biologicals Category Peptide Species Human

DYRK2-Antibody-C-term-Blocking-Peptide - BP14410b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DYRK2-Antibody-N-term-Blocking-Peptide - BP7534a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DYRK2 - H00008445-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DYRK2 - H00008445-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DYRK2 - H00008445-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DYRK2 - H00008445-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DYRK2 - P5541 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

DYRK2 control peptide - AP26123CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

DYRK2 Peptide - 6257P from ProSci Category Peptide Species Human

DYRK2 fusion protein - Ag13480 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

DYRK2 Active Human Recombinant Protein - GWB-63A6A5 from Genway Biotech Category Protein Prices $410.00 Sizes 10 µg Species Human

Recombinant Human DYRK2, His-tagged - DYRK2-518H from Creative Biomart Category Protein Source Sf9 .

Search more