| Gene Symbol |
SLC38A9
|
| Entrez Gene |
153129
|
| Alt Symbol |
URLC11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 38, member 9
|
| Other Description |
putative sodium-coupled neutral amino acid transporter 9|sodium-coupled neutral amino acid transporter 9|solute carrier family 38 member 9|up-regulated in lung cancer 11
|
| Swissprots |
B3KXV1 Q0P5S0 Q8NBW4 Q6MZJ8 B7Z7D0 A0A0A8K8P2
|
| Accessions |
CAF86482 CAH05625 EAW54925 EAW54926 EAW54927 EAW54928 Q8NBW4 AB105188 BAQ19756 AI580489 AK075190 BAC11460 AK122957 BAG53820 AK127988 BAG54613 AK128743 AK301850 BAH13566 BC036232 BC045589 BC066891 AAH66891 BC101361 BC101362 AAI01363 BU632379 BX641065 CAE46032 DC371481 XM_006714537 XP_006714600 XM_006714538 XP_006714601 XM_006714539 XP_006714602 XM_011543173 XP_011541475 XM_011543174 XP_011541476 XM_011543175 XP_011541477 XM_011543176 XP_011541478 XM_011543177 XP_011541479 XM_011543178 XP_011541480 XM_011543179 XP_011541481 XM_011543180 XP_011541482 XM_011543181 XP_011541483 XM_011543182 XP_011541484 XM_011543183 XP_011541485 XM_011543184 XP_011541486 XR_948237 XR_948238 NM_001258286 NP_001245215 NM_001258287 NP_001245216 NM_001282429 NP_001269358 NM_173514 NP_775785 NR_047649
|
| Function |
Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25561175, PubMed:25567906). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids, suggesting that it acts as an amino acid sensor instead (PubMed:25561175, PubMed:25567906). The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor (PubMed:25567906). {ECO:0000269|PubMed:25561175, ECO:0000269|PubMed:25567906}.
|
| Subcellular Location |
Lysosome membrane {ECO:0000269|PubMed:25561175, ECO:0000269|PubMed:25567906}; Multi- pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:25561175}; Multi-pass membrane protein {ECO:0000255}.
|