SLC38A9

Gene Symbol SLC38A9
Entrez Gene 153129
Alt Symbol URLC11
Species Human
Gene Type protein-coding
Description solute carrier family 38, member 9
Other Description putative sodium-coupled neutral amino acid transporter 9|sodium-coupled neutral amino acid transporter 9|solute carrier family 38 member 9|up-regulated in lung cancer 11
Swissprots B3KXV1 Q0P5S0 Q8NBW4 Q6MZJ8 B7Z7D0 A0A0A8K8P2
Accessions CAF86482 CAH05625 EAW54925 EAW54926 EAW54927 EAW54928 Q8NBW4 AB105188 BAQ19756 AI580489 AK075190 BAC11460 AK122957 BAG53820 AK127988 BAG54613 AK128743 AK301850 BAH13566 BC036232 BC045589 BC066891 AAH66891 BC101361 BC101362 AAI01363 BU632379 BX641065 CAE46032 DC371481 XM_006714537 XP_006714600 XM_006714538 XP_006714601 XM_006714539 XP_006714602 XM_011543173 XP_011541475 XM_011543174 XP_011541476 XM_011543175 XP_011541477 XM_011543176 XP_011541478 XM_011543177 XP_011541479 XM_011543178 XP_011541480 XM_011543179 XP_011541481 XM_011543180 XP_011541482 XM_011543181 XP_011541483 XM_011543182 XP_011541484 XM_011543183 XP_011541485 XM_011543184 XP_011541486 XR_948237 XR_948238 NM_001258286 NP_001245215 NM_001258287 NP_001245216 NM_001282429 NP_001269358 NM_173514 NP_775785 NR_047649
Function Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25561175, PubMed:25567906). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids, suggesting that it acts as an amino acid sensor instead (PubMed:25561175, PubMed:25567906). The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor (PubMed:25567906). {ECO:0000269|PubMed:25561175, ECO:0000269|PubMed:25567906}.
Subcellular Location Lysosome membrane {ECO:0000269|PubMed:25561175, ECO:0000269|PubMed:25567906}; Multi- pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:25561175}; Multi-pass membrane protein {ECO:0000255}.

SLC38A9 (P-17) - sc-248638 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SLC38A9 (T-20) - sc-248639 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SLC38A9 antibody - ab130398 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent staining of Human cell line U-251 MG shows positivity in nucleus but not nucleoli and vesicles. Recommended concentration of ab130398 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Anti-SLC38A9 antibody - ab81687 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SLC38A9 antibody (ab81687) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SLC38A9 Antibody (aa218-267) - LS-C82726 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

SLC38A9 Antibody - NBP1-92403 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: SLC38A9 Antibody [NBP1-92403] - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.

SLC38A9 Antibody - NBP1-69235 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SLC38A9 Antibody [NBP1-69235] - This Anti-FLJ90709 antibody was used in Western Blot of Jurkat tissue lysate at a concentration of 1ug/ml.

Anti-FLJ90709 antibody produced in rabbit - AV53259 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: Jurkat (<B>Cat. No. AV53259</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type Jurkat

Anti-SLC38A9 antibody produced in rabbit - HPA043785 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SLC38A9: <B>Cat. No. HPA043785</B>: Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.

SLC38A9 antibody - middle region (ARP53259_P050) - ARP53259_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FLJ90709 antibody, Internal - GTX45575 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-FLJ90709 antibody, Internal used in Western blot. GTX45575

FLJ90709 antibody - 70R-7082 from Fitzgerald

Host Rabbit
Clonality Polyclonal

FLJ90709 Antibody - 26-766 from ProSci

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

FLJ90709 Antibody - GWB-MS995E from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC38A9 (aa 5-105) polyclonal antibody - DPABH-24484 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

SLC38A9 antibody - TA337782 from Acris Antibodies

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
WB Suggested Anti-SLC38A9 Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate

SLC38A9 Antibody,Biotin conjugated - CSB-PA836713LD01HU from Cusabio

Host Rabbit
Clonality Polyclonal

SLC38A9 Antibody,FITC conjugated - CSB-PA836713LC01HU from Cusabio

Host Rabbit
Clonality Polyclonal

SLC38A9 Antibody,HRP conjugated - CSB-PA836713LB01HU from Cusabio

Host Rabbit
Clonality Polyclonal

SLC38A9 Antibody - CSB-PA836713LA01HU from Cusabio

Host Rabbit
Clonality Polyclonal

SLC38A9 Polyclonal Antibody - CAC07667 from Biomatik

Prices $179.00, $323.00
Sizes 50 μg, 100 μg
Host Rabbit
Clonality Polyclonal

SLC38A9 antibody - middle region : Biotin (ARP53259_P050-Biotin) - ARP53259_P050-Biotin from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

SLC38A9 antibody - middle region : FITC (ARP53259_P050-FITC) - ARP53259_P050-FITC from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

SLC38A9 antibody - middle region : HRP (ARP53259_P050-HRP) - ARP53259_P050-HRP from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal

Anti-SLC38A9 Antibody (aa218-267, HRP) - LS-C457311 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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