| Gene Symbol |
Rapgef4
|
| Entrez Gene |
56508
|
| Alt Symbol |
1300003D15Rik, 5730402K07Rik, 6330581N18Rik, EPAC 2, Epac-2, Epac2, mKIAA4040
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
Rap guanine nucleotide exchange factor (GEF) 4
|
| Other Description |
cAMP-GEFII|cAMP-dependent Rap1 guanine-nucleotide exchange factor|cAMP-regulated guanine nucleotide exchange factor IIB|exchange factor directly activated by cAMP 2|exchange protein directly activated by cAMP 2|rap guanine nucleotide exchange factor 4
|
| Swissprots |
Q9Z1P0 Q9CW52 Q8VIP9 Q9EQZ6
|
| Accessions |
CDM22141 EDL27106 EDL27107 EDL27108 Q9EQZ6 AB021132 BAB18976 AB037668 BAB72180 AB445011 BAH30656 AF115480 AAD09132 AK004874 BAB23633 AK017479 BAB30763 AK032089 AK046900 AK080066 AK135084 AK161934 AK203721 AK220281 BAD90206 BC139822 AAI39823 BP767789 CK622268 XM_006499938 XP_006500001 XM_011239711 XP_011238013 NM_001204165 NP_001191094 NM_001204166 NP_001191095 NM_001204167 NP_001191096 NM_019688 NP_062662
|
| Function |
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2. {ECO:0000269|PubMed:11056535}.
|
| Subcellular Location |
Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in cerebellum, pituitary, adrenal gland and liver. {ECO:0000269|PubMed:11056535}.
|
| Top Pathways |
Leukocyte transendothelial migration, Adrenergic signaling in cardiomyocytes, cAMP signaling pathway, Rap1 signaling pathway
|