Phactr4

Gene Symbol Phactr4
Entrez Gene 100169
Alt Symbol 3110001B12Rik, AI527228, AW495572, C330013F19Rik, N28169, mKIAA4120
Species Mouse
Gene Type protein-coding
Description phosphatase and actin regulator 4
Other Description humdy|protein Humpty dumpty
Swissprots A2ALF7 Q6DI97 Q8C7U9 F6QNZ3 Q5DTM4 A2ALG0 Q501J7
Accessions EDL30104 Q501J7 AK013935 AK029356 AK049209 BAC33611 AK220496 BAD90294 BB849287 BC037059 BC075672 AAH75672 BC096033 AAH96033 BY294063 CN460852 XM_006538456 XP_006538519 XM_006538457 XP_006538520 XM_011250172 XP_011248474 NM_001161797 NP_001155269 NM_175306 NP_780515
Function Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway. {ECO:0000269|PubMed:17609112, ECO:0000269|PubMed:22215812}.
Subcellular Location Cytoplasm. Cell projection, lamellipodium.

Recombinant Mouse Phosphatase and actin regulator 4(Phactr4) - CSB-YP017883MO CSB-EP017883MO CSB-BP017883MO CSB-MP017883MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Phosphatase and actin regulator 4 (Phactr4), Recombinant Protein - MBS1293401 from MyBioSource

Category Protein
Prices $1,500.00, $1,500.00, $1,730.00, $1,730.00, $2,560.00, $2,560.00, $3,005.00, $3,005.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Recombinant Mouse PHACTR4 Protein - PHACTR4-12706M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse
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