Phactr4

Gene Symbol Phactr4
Entrez Gene 100169
Alt Symbol 3110001B12Rik, AI527228, AW495572, C330013F19Rik, N28169, mKIAA4120
Species Mouse
Gene Type protein-coding
Description phosphatase and actin regulator 4
Other Description humdy|protein Humpty dumpty
Swissprots A2ALF7 Q6DI97 Q8C7U9 F6QNZ3 Q5DTM4 A2ALG0 Q501J7
Accessions EDL30104 Q501J7 AK013935 AK029356 AK049209 BAC33611 AK220496 BAD90294 BB849287 BC037059 BC075672 AAH75672 BC096033 AAH96033 BY294063 CN460852 XM_006538456 XP_006538519 XM_006538457 XP_006538520 XM_011250172 XP_011248474 NM_001161797 NP_001155269 NM_175306 NP_780515
Function Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway. {ECO:0000269|PubMed:17609112, ECO:0000269|PubMed:22215812}.
Subcellular Location Cytoplasm. Cell projection, lamellipodium.

PHACTR4 CRISPR/Cas9 KO Plasmid (m) - sc-430303 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PHACTR4 HDR Plasmid (m) - sc-430303-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PHACTR4 Double Nickase Plasmid (m) - sc-430303-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PHACTR4 Double Nickase Plasmid (m2) - sc-430303-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PHACTR4 CRISPR Activation Plasmid (m) - sc-430303-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PHACTR4 CRISPR Activation Plasmid (m2) - sc-430303-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PHACTR4 Lentiviral Activation Particles (m) - sc-430303-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PHACTR4 Lentiviral Activation Particles (m2) - sc-430303-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PHACTR4 siRNA (m) - sc-106405 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

PHACTR4 shRNA Plasmid (m) - sc-106405-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

PHACTR4 shRNA (m) Lentiviral Particles - sc-106405-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU087971 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® Long Non-Coding esiRNA - EMNC000721 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN38627 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38627 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PHACTR4 siRNA (Mouse) - CRN0462 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse PHACTR4 (NM_175306.4) - SHH374508 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse PHACTR4 siRNA - orb289937 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

PHACTR4 shRNA Plasmid (Mouse) - CHN0462 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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