| Gene Symbol |
MTA3
|
| Entrez Gene |
57504
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
metastasis associated 1 family, member 3
|
| Other Description |
metastasis associated family, member 3|metastasis associated gene family, member 3|metastasis-associated protein MTA3
|
| Swissprots |
Q9NSP2 Q9BTC8 Q9ULF4
|
| Accessions |
AAY14699 AAY24040 AAY24110 EAX00313 EAX00314 EAX00315 EAX00316 EAX00317 Q9BTC8 AB033092 BAA86580 AF086450 AK027304 BAB55028 AK122690 AK127245 AL161954 CAB82305 AW292870 BC004227 AAH04227 BC053631 AAH53631 BU859486 CA447673 DA239202 DB335600 XM_005264456 XP_005264513 XM_005264458 XP_005264515 XM_005264459 XP_005264516 XM_011533006 XP_011531308 XR_939697 XR_939698 NM_001282755 NP_001269684 NM_001282756 NP_001269685 NM_020744 NP_065795
|
| Function |
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6. {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:12705869}.
|
| Tissue Specificity |
Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells. {ECO:0000269|PubMed:12705869}.
|