Gene Symbol | MTA3 |
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Entrez Gene | 57504 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | metastasis associated 1 family, member 3 |
Other Description | metastasis associated family, member 3|metastasis associated gene family, member 3|metastasis-associated protein MTA3 |
Swissprots | Q9NSP2 Q9BTC8 Q9ULF4 |
Accessions | AAY14699 AAY24040 AAY24110 EAX00313 EAX00314 EAX00315 EAX00316 EAX00317 Q9BTC8 AB033092 BAA86580 AF086450 AK027304 BAB55028 AK122690 AK127245 AL161954 CAB82305 AW292870 BC004227 AAH04227 BC053631 AAH53631 BU859486 CA447673 DA239202 DB335600 XM_005264456 XP_005264513 XM_005264458 XP_005264515 XM_005264459 XP_005264516 XM_011533006 XP_011531308 XR_939697 XR_939698 NM_001282755 NP_001269684 NM_001282756 NP_001269685 NM_020744 NP_065795 |
Function | Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6. {ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:15454082}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:12705869}. |
Tissue Specificity | Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells. {ECO:0000269|PubMed:12705869}. |
MTA3 CRISPR/Cas9 KO Plasmid (h) - sc-402739 from Santa Cruz Biotechnology
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MTA3 HDR Plasmid (h) - sc-402739-HDR from Santa Cruz Biotechnology
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MTA3 Double Nickase Plasmid (h) - sc-402739-NIC from Santa Cruz Biotechnology
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MTA3 Double Nickase Plasmid (h2) - sc-402739-NIC-2 from Santa Cruz Biotechnology
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MTA3 CRISPR Activation Plasmid (h) - sc-402739-ACT from Santa Cruz Biotechnology
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MTA3 CRISPR Activation Plasmid (h2) - sc-402739-ACT-2 from Santa Cruz Biotechnology
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MTA3 Lentiviral Activation Particles (h) - sc-402739-LAC from Santa Cruz Biotechnology
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MTA3 Lentiviral Activation Particles (h2) - sc-402739-LAC-2 from Santa Cruz Biotechnology
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MTA3 siRNA (h) - sc-43948 from Santa Cruz Biotechnology
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MTA3 shRNA Plasmid (h) - sc-43948-SH from Santa Cruz Biotechnology
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MTA3 shRNA (h) Lentiviral Particles - sc-43948-V from Santa Cruz Biotechnology
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MTA3 RNAi - H00057504-R01 from Novus Biologicals
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MISSION® esiRNA - EHU031591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14686 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14686 from Sigma-Aldrich
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MTA3 siRNA (Human) - CRJ1490 from Cohesion Biosciences
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shRNA set against Human MTA3 (NM_020744.2) - SHH346076 from Creative biogene
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shRNA set against Human MTA3(NM_020744.2) - SHH205031 from Creative biogene
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Human MTA3 siRNA - orb271991 from Biorbyt
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MTA3 shRNA Plasmid (Human) - CHJ1490 from Cohesion Biosciences
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MTA3 miRNA 3'UTR clone - MiUTR1H-06497 from Creative biogene
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