Gene Symbol | EFTUD1 |
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Entrez Gene | 79631 |
Alt Symbol | FAM42A, HsT19294, RIA1 |
Species | Human |
Gene Type | protein-coding |
Description | elongation factor Tu GTP binding domain containing 1 |
Other Description | elongation factor Tu GTP-binding domain-containing protein 1|elongation factor-like 1|ribosome assembly 1 homolog |
Swissprots | B7Z6I0 Q9H8Z6 A6NKY5 Q7Z2Z2 |
Accessions | EAW99087 EAW99088 EAW99089 Q7Z2Z2 AK023181 BAB14450 AK056656 BAG51777 AK300348 BAH13266 BC014628 BC041565 BC152910 AAI52911 BC156743 AAI56744 BG204990 BX538332 CAD98101 DA260259 XM_011521998 XP_011520300 XM_011521999 XP_011520301 XM_011522000 XP_011520302 XR_931901 NM_001040610 NP_001035700 NM_024580 NP_078856 |
Function | Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits. {ECO:0000269|PubMed:21536732}. |
Top Pathways | Ribosome biogenesis in eukaryotes |
RIA1 CRISPR/Cas9 KO Plasmid (h) - sc-413191 from Santa Cruz Biotechnology
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RIA1 HDR Plasmid (h) - sc-413191-HDR from Santa Cruz Biotechnology
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RIA1 Double Nickase Plasmid (h) - sc-413191-NIC from Santa Cruz Biotechnology
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RIA1 Double Nickase Plasmid (h2) - sc-413191-NIC-2 from Santa Cruz Biotechnology
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RIA1 CRISPR Activation Plasmid (h) - sc-413191-ACT from Santa Cruz Biotechnology
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RIA1 CRISPR Activation Plasmid (h2) - sc-413191-ACT-2 from Santa Cruz Biotechnology
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RIA1 Lentiviral Activation Particles (h) - sc-413191-LAC from Santa Cruz Biotechnology
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RIA1 Lentiviral Activation Particles (h2) - sc-413191-LAC-2 from Santa Cruz Biotechnology
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RIA1 siRNA (h) - sc-90234 from Santa Cruz Biotechnology
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RIA1 shRNA Plasmid (h) - sc-90234-SH from Santa Cruz Biotechnology
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RIA1 shRNA (h) Lentiviral Particles - sc-90234-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU157371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7705 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7705 from Sigma-Aldrich
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EFTUD1 siRNA (Human) - CRJ2440 from Cohesion Biosciences
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EFTUD1 - MBS8230895 from MyBioSource
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shRNA set against Human EFTUD1 (NM_024580.5) - SHH283753 from Creative biogene
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shRNA set against Human EFTUD1(NM_001040610.2) - SHH026129 from Creative biogene
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EFTUD1 shRNA Plasmid (Human) - CHJ2440 from Cohesion Biosciences
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EFTUD1 miRNA 3'UTR clone - MiUTR1H-03133 from Creative biogene
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EFTUD1 miRNA 3'UTR clone - MiUTR1H-03134 from Creative biogene
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