VIL1

Gene Symbol	VIL1
Entrez Gene	7429
Alt Symbol	D2S1471, VIL
Species	Human
Gene Type	protein-coding
Description	villin 1
Other Description	villin-1
Swissprots	Q96AC8 B2R9A7 Q53S11 P09327
Accessions	AAY14886 CAA00664 CAA50375 CAJ46927 EAW70619 EAW70620 P09327 A14103 CAA01148 AK223398 BAD97118 AK300965 BAG62590 AK313709 BAG36454 BC017303 AAH17303 BP329402 X04657 CAA28355 X12901 CAA31386 NM_007127 NP_009058
Function	Epithelial cell-specific Ca(2+)-regulated actin- modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity
Subcellular Location	Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, microvillus. Cell projection, filopodium tip {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Relocalized in the tip of cellular protrusions and filipodial extensions upon infection with S.flexneri in primary intestinal epithelial cells (IEC) and in the tail-like structures forming the actin comets of S.flexneri. Redistributed to the leading edge of hepatocyte growth factor (HGF)-induced lamellipodia (By similarity). Rapidly redistributed to ruffles and lamellipodia structures in response to autotaxin, lysophosphatidic acid (LPA) and epidermal growth factor (EGF) treatment. {ECO:0000250}.
Tissue Specificity	Specifically expressed in epithelial cells. Major component of microvilli of intestinal epithelial cells and kidney proximal tubule cells. Expressed in canalicular microvilli of hepatocytes (at protein level). {ECO:0000269|PubMed:14550699, ECO:0000269|PubMed:3453110}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Villin full length protein - ab152794 from Abcam Category Protein Source Wheat germ Species Human

Human Villin protein fragment - ab152796 from Abcam Category Protein Source Wheat germ Species Human

VIL1 / Villin Antibody Blocking Peptide - LS-E23682 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VIL1 / Villin Antibody Blocking Peptide - LS-E8450 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Villin 1 Protein - H00007429-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Villin 1 Recombinant Protein - H00007429-P02 from Novus Biologicals Category Protein Species Human

Recombinant Human Villin 1 Protein - H00007429-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Villin-1-Antibody-N-term-Blocking-Peptide - BP6774a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Villin-1 - H00007429-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Villin-1 - H00007429-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Villin-1 - H00007429-P02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Villin-1 - H00007429-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Villin-1 - H00007429-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Villin-1 - H00007429-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

VIL1 fusion protein - Ag9637 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

VIL1 fusion protein - Ag9610 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human VIL1, His-tagged - VIL1-3661H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Villin 1 (VIL1) - RPC595Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Villin 1 (VIL1) - RPC595Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Villin-1(VIL1) - CSB-YP025855HU CSB-EP025855HU CSB-BP025855HU CSB-MP025855HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Villin 1 Protein (Recombinant) - abx166556 from Abbexa Category Protein Source Human Species Human

Villin-1 - TP316340 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Villin 1, Recombinant Protein - MBS2029498 from MyBioSource Category Protein Prices $235.00, $415.00, $595.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Villin-1 (VIL1), Recombinant Protein - MBS965451 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast Species Human

Villin 1 Recombinant Protein Antigen - NBP1-85336PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Search more