Gene Symbol | CDKN2C |
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Entrez Gene | 1031 |
Alt Symbol | INK4C, p18, p18-INK4C |
Species | Human |
Gene Type | protein-coding |
Description | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) |
Other Description | CDK6 inhibitor p18|cyclin-dependent inhibitor|cyclin-dependent kinase 4 inhibitor C|cyclin-dependent kinase 6 inhibitor p18|p18-INK6 |
Swissprots | Q8TB83 P42773 |
Accessions | AAC39783 AAF28398 AAM11873 CBX47327 EAX06833 EAX06834 EAX06835 EAX06836 P42773 AF041248 AAC39782 AK021794 AK091170 BAG52297 BC000598 AAH00598 BC005041 AAH05041 BC016173 AAH16173 BC017036 BE783451 BE831176 CR450289 CAG29285 DQ891516 ABM82442 DQ894707 ABM85633 U17074 AAC50074 NM_001262 NP_001253 NM_078626 NP_523240 |
Function | Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. |
Tissue Specificity | Highest levels found in skeletal muscle. Also found in pancreas and heart. |
Top Pathways | Cell cycle, HTLV-I infection, Transcriptional misregulation in cancer |
p18 CRISPR/Cas9 KO Plasmid (h) - sc-401214 from Santa Cruz Biotechnology
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p18 HDR Plasmid (h) - sc-401214-HDR from Santa Cruz Biotechnology
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p18 Double Nickase Plasmid (h) - sc-401214-NIC from Santa Cruz Biotechnology
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p18 Double Nickase Plasmid (h2) - sc-401214-NIC-2 from Santa Cruz Biotechnology
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p18 CRISPR Activation Plasmid (h) - sc-401214-ACT from Santa Cruz Biotechnology
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p18 CRISPR Activation Plasmid (h2) - sc-401214-ACT-2 from Santa Cruz Biotechnology
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p18 Lentiviral Activation Particles (h) - sc-401214-LAC from Santa Cruz Biotechnology
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p18 Lentiviral Activation Particles (h2) - sc-401214-LAC-2 from Santa Cruz Biotechnology
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p18 siRNA (h) - sc-36145 from Santa Cruz Biotechnology
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p18 shRNA Plasmid (h) - sc-36145-SH from Santa Cruz Biotechnology
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p18 shRNA (h) Lentiviral Particles - sc-36145-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN5867 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5867 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03010 from Sigma-Aldrich
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CDKN2C siRNA (Human) - CRH0744 from Cohesion Biosciences
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CDKN2C - MBS8237394 from MyBioSource
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p18 CRISPR/Cas9 KO Plasmid (h2) - sc-401214-KO-2 from Santa Cruz Biotechnology
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p18 HDR Plasmid (h2) - sc-401214-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CDKN2C (NM_078626.2) - SHH260893 from Creative biogene
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shRNA set against Human CDKN2C(NM_078626.2) - SHG165563 from Creative biogene
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shRNA set against Human CDKN2C(NM_001262.2) - SHG165627 from Creative biogene
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Human CDKN2C siRNA - orb261246 from Biorbyt
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CDKN2C shRNA Plasmid (Human) - CHH0744 from Cohesion Biosciences
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CDKN2C miRNA 3'UTR clone - MiUTR1H-02002 from Creative biogene
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CDKN2C miRNA 3'UTR clone - MiUTR3H-05900 from Creative biogene
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