DKC1

Gene Symbol	DKC1
Entrez Gene	1736
Alt Symbol	CBF5, DKC, DKCX, NAP57, NOLA4, XAP101
Species	Human
Gene Type	protein-coding
Description	dyskeratosis congenita 1, dyskerin
Other Description	CBF5 homolog|H/ACA ribonucleoprotein complex subunit 4|nopp140-associated protein of 57 kDa|nucleolar protein NAP57|nucleolar protein family A member 4|snoRNP protein DKC1
Swissprots	Q9Y505 O60832 Q96G67 F5BSB3 O43845
Accessions	AAD20232 CAA11970 CAB39106 CAB51168 EAW72661 EAW72662 EAW72663 O60832 AF067008 AAD11815 AK225077 AK307672 AM392631 CAL37509 AM392823 CAL37701 BC009928 AAH09928 BC010015 AAH10015 BI858251 BU730947 CD367400 DA429806 DB517187 DQ892737 ABM83663 DQ895984 ABM86910 HY050100 JF279874 ADX66370 KC954523 AGZ20497 KC954524 AGZ20498 KC954525 AGZ20499 U59151 AAB94299 NM_001142463 NP_001135935 NM_001288747 NP_001275676 NM_001363 NP_001354 NR_110021 NR_110022 NR_110023
Function	Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Subcellular Location	Isoform 1: Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:10903840}.
Top Pathways	Ribosome biogenesis in eukaryotes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Dyskerin (C-11) - sc-365731 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Dyskerin (C-15) - sc-26982 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Dyskerin (H-3) - sc-373956 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Dyskerin (H-300) - sc-48794 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Dyskerin (N-17) - sc-26980 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-DKC1 antibody - ab64667 from Abcam Prices $378.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DKC1 antibody - ab174920 from Abcam Prices $384.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DKC1 antibody - ab126049 from Abcam Prices $384.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-DKC1 antibody - ab60174 from Abcam Prices $378.00 Sizes 200 µl Host Goat Clonality Polyclonal

Anti-DKC1 antibody - ab64955 from Abcam Prices $378.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DKC1 antibody [EPR10398] - ab156006 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR10398

Anti-DKC1 antibody [EPR10399] - ab156877 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR10399

Anti-DKC1 / Dyskerin Antibody (aa185-213, AP) - LS-C213555 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKC1 / Dyskerin Antibody (aa185-213, APC) - LS-C213556 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKC1 / Dyskerin Antibody (aa185-213, Biotin) - LS-C213557 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKC1 / Dyskerin Antibody - LS-C192756 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DKC1 / Dyskerin Antibody (aa185-213, FITC) - LS-C213558 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKC1 / Dyskerin Antibody (aa35-84) - LS-C110511 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DKC1 / Dyskerin Antibody (aa185-213, PE) - LS-C213560 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKC1 / Dyskerin Antibody (aa185-213, Azide-free, HRP) - LS-C213559 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DKC1 / Dyskerin Antibody - LS-C307888 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-DKC1 / Dyskerin Antibody (aa340-390) - LS-C289322 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DKC1 / Dyskerin Antibody (aa390-440) - LS-C289324 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DKC1 / Dyskerin Antibody (Lys203) - LS-C176706 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DKC1 / Dyskerin Antibody (aa171-220) - LS-C118703 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Search more