DKC1

Gene Symbol	DKC1
Entrez Gene	1736
Alt Symbol	CBF5, DKC, DKCX, NAP57, NOLA4, XAP101
Species	Human
Gene Type	protein-coding
Description	dyskeratosis congenita 1, dyskerin
Other Description	CBF5 homolog|H/ACA ribonucleoprotein complex subunit 4|nopp140-associated protein of 57 kDa|nucleolar protein NAP57|nucleolar protein family A member 4|snoRNP protein DKC1
Swissprots	Q9Y505 O60832 Q96G67 F5BSB3 O43845
Accessions	AAD20232 CAA11970 CAB39106 CAB51168 EAW72661 EAW72662 EAW72663 O60832 AF067008 AAD11815 AK225077 AK307672 AM392631 CAL37509 AM392823 CAL37701 BC009928 AAH09928 BC010015 AAH10015 BI858251 BU730947 CD367400 DA429806 DB517187 DQ892737 ABM83663 DQ895984 ABM86910 HY050100 JF279874 ADX66370 KC954523 AGZ20497 KC954524 AGZ20498 KC954525 AGZ20499 U59151 AAB94299 NM_001142463 NP_001135935 NM_001288747 NP_001275676 NM_001363 NP_001354 NR_110021 NR_110022 NR_110023
Function	Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Subcellular Location	Isoform 1: Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:10903840}.
Top Pathways	Ribosome biogenesis in eukaryotes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DKC1 full length protein - ab152334 from Abcam Category Protein Source Wheat germ Species Human

Human DKC1 peptide - ab71334 from Abcam Category Peptide

Human DKC1 protein fragment - ab152335 from Abcam Category Protein Source Wheat germ Species Human

DKC1 / Dyskerin Antibody Blocking Peptide - LS-E14707 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKC1 / Dyskerin Antibody Blocking Peptide - LS-E7854 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKC1 / Dyskerin Antibody Blocking Peptide - LS-E26299 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DKC1 Protein - H00001736-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DKC1 Recombinant Protein - H00001736-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

DKC1-Antibody-Center-Blocking-peptide - BP5479c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DKC1 blocking peptide - GTX89097-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

DKC1 Blocking Peptide - 33R-2407 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DKC1 Peptide - AC21-1131-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DKC1 / NOLA4 - H00001736-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

DKC1 / NOLA4 - H00001736-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DKC1 / NOLA4 - H00001736-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DKC1 Peptide - 45-483P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

DKC1 fusion protein - ag1239 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

DKC1 fusion protein - ag7992 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human DKC1 protein, GST-tagged - DKC1-261H from Creative Biomart Category Protein Source Wheat Germ Species Human

Dyskerin (K203) Peptide - BS1887P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human H/ACA ribonucleoprotein complex subunit 4(DKC1) - CSB-YP006919HU CSB-EP006919HU CSB-BP006919HU CSB-MP006919HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DKC1, Peptide - MBS425350 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

Recombinant Dyskerin (DKC) - RPC446Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Dyskerin (DKC) - RPC446Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Dyskerin (DKC) - RPC446Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Search more