| Gene Symbol | GRIA3 |
|---|---|
| Entrez Gene | 2892 |
| Alt Symbol | GLUR-C, GLUR-K3, GLUR3, GLURC, GluA3, MRX94 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamate receptor, ionotropic, AMPA 3 |
| Other Description | AMPA-selective glutamate receptor 3|dJ1171F9.1|gluR-3|glutamate receptor 3|glutamate receptor C|glutamate receptor subunit 3|glutamate receptor, ionotrophic, AMPA 3 |
| Swissprots | Q9HDA1 Q4VXD5 D3DTF1 Q9P0H1 Q9HDA2 Q4VXD6 P42263 Q9HDA0 |
| Accessions | AAF23961 AAF61847 AAF61848 AAF97857 AAF97858 AAF97859 EAX11865 EAX11866 EAX11867 P42263 AK297136 BAH12506 AW166130 BC032004 AAH32004 BC117464 AAI17465 BE504553 BY799542 DA158269 DA179917 DA180344 DA191279 DB505790 HQ258659 ADR83410 U10301 AAA67922 U10302 AAA67923 NM_000828 NP_000819 NM_001256743 NP_001243672 NM_007325 NP_015564 NM_181894 |
| Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:21172611}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}. |
| Top Pathways | cAMP signaling pathway, Circadian entrainment, Retrograde endocannabinoid signaling, Nicotine addiction, Amphetamine addiction |