Gene Symbol | EFNA3 |
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Entrez Gene | 1944 |
Alt Symbol | EFL2, EPLG3, Ehk1-L, LERK3 |
Species | Human |
Gene Type | protein-coding |
Description | ephrin-A3 |
Other Description | EFL-2|EHK1 ligand|LERK-3|eph-related receptor tyrosine kinase ligand 3|ligand of eph-related kinase 3 |
Swissprots | Q5SR70 B7ZAD3 Q0VGC9 P52797 D3DV85 |
Accessions | EAW53136 EAW53137 P52797 AK296030 BAG58798 AK316248 BAH14619 BC017722 AAH17722 BC110406 AAI10407 BU633345 DQ891668 ABM82594 DQ894854 ABM85780 L37360 AAA52368 U14187 AAC50078 NM_004952 NP_004943 |
Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
Tissue Specificity | Expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes. |
Top Pathways | Axon guidance, PI3K-Akt signaling pathway, MicroRNAs in cancer, Rap1 signaling pathway |
EFNA3 overexpression lysate - LY417629 from Acris Antibodies
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EFNA3 293 Cell Lysate - 408256 from ABBIOTEC
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Ephrin-A3 Overexpression Lysate (Native) - NBL1-10144 from Novus Biologicals
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ephrin-A3 (h2): 293T Lysate - sc-176244 from Santa Cruz Biotechnology
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ephrin-A3 (h3): 293T Lysate - sc-176339 from Santa Cruz Biotechnology
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ephrin-A3 (h4): 293T Lysate - sc-110072 from Santa Cruz Biotechnology
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EFNA3 Over-expression Lysate Product - GWB-46F23E from Genway Biotech
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Human Ephrin-A3 / EFNA3 HEK293 Cell Lysate (WB positive control) - 10188-HCCHL-300 from Sino Biological
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Human Ephrin-A3 / EFNA3 HEK293 Cell Lysate (WB positive control) - 10188-H08HL-300 from Sino Biological
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Human Ephrin-A3 / EFNA3 HEK293 Cell Lysate (WB positive control) - 10188-H03HL-300 from Sino Biological
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Human Ephrin-A3 / EFNA3 / EFL2 HEK293 Cell Lysate (WB positive control) - 10188-H02HL-300 from Sino Biological
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Ephrin-A3 Overexpression Lysate (Denatured) - H00001944-T02 from Novus Biologicals
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Ephrin-A3 Overexpression Lysate (Denatured) - H00001944-T01 from Novus Biologicals
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Panoply™ Human EFNA3 Knockdown Stable Cell Line - CSC-DC004756 from Creative biogene
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