Gene Symbol | EFNA3 |
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Entrez Gene | 1944 |
Alt Symbol | EFL2, EPLG3, Ehk1-L, LERK3 |
Species | Human |
Gene Type | protein-coding |
Description | ephrin-A3 |
Other Description | EFL-2|EHK1 ligand|LERK-3|eph-related receptor tyrosine kinase ligand 3|ligand of eph-related kinase 3 |
Swissprots | Q5SR70 B7ZAD3 Q0VGC9 P52797 D3DV85 |
Accessions | EAW53136 EAW53137 P52797 AK296030 BAG58798 AK316248 BAH14619 BC017722 AAH17722 BC110406 AAI10407 BU633345 DQ891668 ABM82594 DQ894854 ABM85780 L37360 AAA52368 U14187 AAC50078 NM_004952 NP_004943 |
Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
Tissue Specificity | Expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes. |
Top Pathways | Axon guidance, PI3K-Akt signaling pathway, MicroRNAs in cancer, Rap1 signaling pathway |
ephrin-A3 (D-8) - sc-393727 from Santa Cruz Biotechnology
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ephrin-A3 (G-11) - sc-398331 from Santa Cruz Biotechnology
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ephrin-A3 (H-90) - sc-20720 from Santa Cruz Biotechnology
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ephrin-A3 (K-19) - sc-1012 from Santa Cruz Biotechnology
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ephrin-A3 (12EXZ) - sc-73954 from Santa Cruz Biotechnology
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Anti-Ephrin A3 antibody - ab168794 from Abcam
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Anti-Ephrin A3 antibody - ab64814 from Abcam
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Anti-Ephrin A3 antibody [MM0262-7N12] - ab89472 from Abcam
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Anti-EFNA3 / Ephrin A3 Antibody (C-Terminus) - LS-C6547 from LifeSpan Bioscience
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Anti-EFNA3 / Ephrin A3 Antibody - LS-C307913 from LifeSpan Bioscience
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Anti-EFNA3 / Ephrin A3 Antibody - LS-C310220 from LifeSpan Bioscience
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Anti-EFNA3 / Ephrin A3 Antibody (aa161-210) - LS-C118935 from LifeSpan Bioscience
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Anti-EFNA3 / Ephrin A3 Antibody (clone 1C12) - LS-C197113 from LifeSpan Bioscience
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Anti-EFNA3 / Ephrin A3 Antibody (aa23-214, clone 4A4) - LS-C339819 from LifeSpan Bioscience
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Anti-EFNA3 / Ephrin A3 Antibody (Glu196) - LS-C176779 from LifeSpan Bioscience
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Ephrin-A3 Antibody - NBP1-19540 from Novus Biologicals
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Ephrin-A3 Antibody [Unconjugated] - AF359 from Novus Biologicals
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Ephrin-A3 Antibody - NBP1-67968 from Novus Biologicals
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Ephrin-A3 Antibody - H00001944-B01P from Novus Biologicals
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Ephrin-A3 Antibody - H00001944-D01P from Novus Biologicals
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Ephrin-A3 Antibody - NBP2-14949 from Novus Biologicals
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Ephrin-A3 Antibody (MM0262-7N12) - NBP2-12279 from Novus Biologicals
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Ephrin-A3 Antibody - H00001944-A01 from Novus Biologicals
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Ephrin-A3 Antibody [Biotin] - BAF359 from Novus Biologicals
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Ephrin-A3 Antibody (2H3) - H00001944-M10 from Novus Biologicals
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