Gene Symbol | PSAP |
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Entrez Gene | 5660 |
Alt Symbol | GLBA, SAP1 |
Species | Human |
Gene Type | protein-coding |
Description | prosaposin |
Other Description | proactivator polypeptide|sphingolipid activator protein-1 |
Swissprots | P07292 Q53Y86 P78547 Q92740 P78541 P07602 Q92742 Q92741 Q6IBQ6 P15793 P78546 Q92739 P78558 P78538 |
Accessions | AAC64921 AAG31635 CAA40391 CAA40392 CCQ43188 EAW54436 EAW54437 EAW54438 P07602 AB209776 BAD93013 AK057878 AK129790 AK223290 BAD97010 AK293672 BAG57116 AK299184 BAG61229 AK307721 BC001503 AAH01503 BC004275 AAH04275 BC007612 AAH07612 BC091483 AAH91483 BT006849 AAP35495 CR456746 CAG33027 D00422 BAA00321 DQ587608 DQ893009 ABM83935 DQ896255 ABM87254 J03015 AAB59494 J03077 AAA52560 M12710 M32221 AAA60303 M60255 AAA36594 M60257 AAA36595 M60258 AAA36596 M81355 NM_001042465 NP_001035930 NM_001042466 NP_001035931 NM_002778 NP_002769 |
Function | Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. |
Subcellular Location | Lysosome {ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:21835174}. |
Top Pathways | Lysosome |
saposin CRISPR/Cas9 KO Plasmid (h) - sc-401394 from Santa Cruz Biotechnology
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saposin HDR Plasmid (h) - sc-401394-HDR from Santa Cruz Biotechnology
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saposin Double Nickase Plasmid (h) - sc-401394-NIC from Santa Cruz Biotechnology
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saposin Double Nickase Plasmid (h2) - sc-401394-NIC-2 from Santa Cruz Biotechnology
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saposin CRISPR Activation Plasmid (h) - sc-401394-ACT from Santa Cruz Biotechnology
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saposin CRISPR Activation Plasmid (h2) - sc-401394-ACT-2 from Santa Cruz Biotechnology
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saposin Lentiviral Activation Particles (h) - sc-401394-LAC from Santa Cruz Biotechnology
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saposin Lentiviral Activation Particles (h2) - sc-401394-LAC-2 from Santa Cruz Biotechnology
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saposin siRNA (h) - sc-44456 from Santa Cruz Biotechnology
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saposin shRNA Plasmid (h) - sc-44456-SH from Santa Cruz Biotechnology
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saposin shRNA (h) Lentiviral Particles - sc-44456-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU061711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17561 from Sigma-Aldrich
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PSAP siRNA (Human) - CRH3815 from Cohesion Biosciences
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shRNA set against Human PSAP (NM_002778.2) - SHH384764 from Creative biogene
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shRNA set against Human PSAP(NM_001042466.1) - SHR145376 from Creative biogene
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shRNA set against Human PSAP(NM_001042465.1) - SHR145384 from Creative biogene
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shRNA set against Human PSAP(NM_001042466.1) - SHR145514 from Creative biogene
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shRNA set against Human PSAP(NM_002778.2) - SHR145542 from Creative biogene
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shRNA set against Human PSAP(NM_001042465.1) - SHR145614 from Creative biogene
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Human PSAP siRNA - orb264317 from Biorbyt
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PSAP shRNA Plasmid (Human) - CHH3815 from Cohesion Biosciences
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PSAP miRNA 3'UTR clone - MiUTR1H-08349 from Creative biogene
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PSAP miRNA 3'UTR clone - MiUTR1H-08350 from Creative biogene
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