| Gene Symbol | CTSD |
|---|---|
| Entrez Gene | 1509 |
| Alt Symbol | CLN10, CPSD, HEL-S-130P |
| Species | Human |
| Gene Type | protein-coding |
| Description | cathepsin D |
| Other Description | ceroid-lipofuscinosis, neuronal 10|epididymis secretory sperm binding protein Li 130P|lysosomal aspartyl peptidase|lysosomal aspartyl protease |
| Swissprots | Q6IB57 P07339 |
| Accessions | AAA16314 AAA51922 AAD13868 AAD14156 EAX02461 EAX02462 EAX02463 P07339 AK130178 BC001574 BC016320 AAH16320 BM762986 BM976200 BT006910 AAP35556 BT020155 AAV38957 CR456947 CAG33228 DQ893547 ABM84473 DQ893878 ABM84804 EU794598 ACJ13652 M11233 AAB59529 X05344 CAA28955 NM_001909 NP_001900 |
| Function | Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. |
| Subcellular Location | Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). {ECO:0000269|PubMed:20551380}. |
| Tissue Specificity | Expressed in the aorta extrcellular space (at protein level). {ECO:0000269|PubMed:20551380}. |
| Top Pathways | Lysosome, Tuberculosis, Sphingolipid signaling pathway |