FGFR3

Gene Symbol FGFR3
Entrez Gene 2261
Alt Symbol ACH, CD333, CEK2, HSFGFR3EX, JTK4
Species Human
Gene Type protein-coding
Description fibroblast growth factor receptor 3
Other Description FGFR-3|fibroblast growth factor receptor 3 variant 4|hydroxyaryl-protein kinase|tyrosine kinase JTK4
Swissprots Q59FL9 D3DVP9 Q16294 P22607 Q14308 Q16608 D3DVQ0
Accessions AAA67781 AAB33323 AAM22078 AAM22079 AAU89726 CAA70981 EAW82562 EAW82563 EAW82564 EAW82565 EAW82566 EAW82567 EAW82568 P22607 AB209441 BAD92678 AF238374 AAF97749 AF245114 AAF63380 AF369211 AAK54727 AF369212 AAK54728 AF369213 AAK54729 AK308936 AW204106 BC121175 AAI21176 BC128610 AAI28611 BC153824 AAI53825 BC166684 AAI66684 DR003490 HM244683 ADM64307 KJ534834 AHW56474 KJ534974 AHW56614 KJ535004 AHW56643 M58051 AAA52450 M59374 AAA63209 M64347 AAA58470 X84939 CAA59334 XM_006713868 XP_006713931 XM_006713869 XP_006713932 XM_006713870 XP_006713933 XM_006713871 XP_006713934 XM_006713872 XP_006713935 XM_006713873 XP_006713936 XM_011513420 XP_011511722 XM_011513422 XP_011511724 NM_000142 NP_000133 NM_001163213 NP_001156685 NM_022965 NP_075254
Function Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.
Subcellular Location Isoform 3: Secreted.
Tissue Specificity Expressed in brain, kidney and testis. Very low or no expression in spleen, heart, and muscle. In 20- to 22- week old fetuses it is expressed at high level in kidney, lung, small intestine and brain, and to a lower degree in spleen, liver, and muscle. Isoform 2 is detected in epithelial cells. Isoform 1 is not detected in epithelial cells. Isoform 1 and isoform 2 are detected in fibroblastic cells. {ECO:0000269|PubMed:1664411}.
Top Pathways PI3K-Akt signaling pathway, Rap1 signaling pathway, Central carbon metabolism in cancer, Signaling pathways regulating pluripotency of stem cells, MicroRNAs in cancer

FGF Receptor 3 (C51F2) Rabbit mAb - 4574 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C51F2
Western blot analysis of recombinant human FGFR-3 cytoplasmic fragment proteins (lane 1) and extracts from KMS-11 cells (lane 2) using FGF Receptor 3 (C51F2) Rabbit mAb.

FGF Receptor 3 (D2G7E) Rabbit mAb - 3163 from Cell Signaling Technology

Host Rabbit
Clonality Monoclonal
Clone D2G7E
Western blot analysis of KMS-11 cell lysates using FGF Receptor 3 (D2G7E) Rabbit mAb.

FGF Receptor 3 Antibody - 3160 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Kms-11 cell lysates using FGF Receptor 3 Antibody.

FGFR-3 (B-9) - sc-13121 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FGFR-3 (B-9): sc-13121. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing membrane staining of epidermal cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

FGFR-3 (E-7) - sc-390423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FGFR-3 (E-7): sc-390423. Western blot analysis of FGFR-3 expression in K-562 whole cell lysate.

FGFR-3 (C-15) - sc-123 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FGFR-3 (C-15): sc-123. Western blot analysis of FGFR-3 expression in A549 (A) and T-47D (B) whole cell lysates.

FGFR-3 (L-14) - sc-31163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

FGFR-3 (H-100) - sc-9007 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FGFR-3 (H-100): sc-9007. Western blot analysis of FGFR-3 expression in K-562 (A), MCF7 (B), T-47D (C) and Hep G2 (D) whole cell lysates and human liver tissue extract (E).

FGFR-3 (P-18) - sc-31162 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-FGFR-3 (Tyr 724) - sc-33041 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-FGFR3 (phospho Y724) antibody [EPR2281(3)] - ab155960 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2281(3)
All lanes : Anti-FGFR3 (phospho Y724) antibody [EPR2281(3)] (ab155960) at 1/5000 dilution (unpurified)Lane 1 : MCF-7 cell lysate (untreated)Lane 2 : MCF-7 cell lysate (treated with pervanadate)Lysates/proteins at 10 µg per lane.SecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-FGFR3 antibody - ab176459 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-FGFR3 antibody (ab176459) at 0.1 µg/mlLane 1 : U87 cell lysateLane 2 : SGC cell lysate

Anti-FGFR3 antibody - ab10651 from Abcam

Prices $373.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-FGFR3 antibody - ab10649 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab10649 stained human HeLa cells. The cells were methanol fixed (5 min) and incubated with the antibody (ab10649, 1µg/ml) for 1h at room temperature. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Image-iTTM FX Signal Enhancer was used as the primary blocking agent, 5% BSA (in TBS-T) was used for all other blocking steps. DAPI was used to stain the cell nuclei (blue). Alexa Fluor® 594 WGA was used to label plasma membranes (red).

Anti-FGFR3 antibody - ab52247 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FGFR3 antibody (ab52247) at 1/300 dilutionLane 1 : LOVO cell extract; without peptideLane 2 : LOVO cell extract; with peptide

Anti-FGFR3 antibody - ab64190 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FGFR3 antibody (ab64190) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : SW480 (Human colon adenocarcinoma cell line) Whole Cell Lysate (ab3957)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-FGFR3 antibody [1G10] - ab156940 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G10
All lanes : Anti-FGFR3 antibody [1G10] (ab156940) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY FGFR3 cDNALysates/proteins at 5 µg per lane.

Anti-FGFR3 antibody [EPR2304(3)] - ab133644 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2304(3)
All lanes : Anti-FGFR3 antibody [EPR2304(3)] (ab133644) at 1/1000 dilution (unpurified)Lane 1 : Fetal brain tissue lysateLane 2 : Fetal kidney tissue lysateLane 3 : K562 cell lysateLane 4 : A549 cell lysateLane 5 : HepG2 cell lysateLane 6 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP-conjugated goat anti-rabbit IgG at 1/2000 dilution

Anti-FGFR3 antibody [EPR2305(3)] - ab137084 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2305(3)
Overlay histogram showing HepG2 cells stained with ab137084 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab137084, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HepG2 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-FGFR3 antibody [MM0279-6G11] - ab89660 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0279-6G11
Overlay histogram showing HepG2 cells stained with ab89660 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab89660, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-FGFR3 antibody, prediluted - ab53636 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab53636 staining human breast carcinoma tissue

Anti-FGFR3 antibody - C-terminal - ab180906 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-FGFR3 antibody - C-terminal (ab180906) at 0.5 µg/mlLane 2 : Anti-FGFR3 antibody - C-terminal (ab180906) at 1 µg/mlLane 1 : SK-N-SH cell lysateLane 2 : SK-N-SH cell lysateLysates/proteins at 15 µg per lane.

Anti-FGFR3 antibody - C-terminal - ab135666 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FGFR3 antibody - C-terminal (ab135666) at 1/100 dilution + Jurkat cell lysate at 12.5 µgdeveloped using the ECL technique

Anti-FGFR3 antibody - C-terminal - ab137799 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FGFR3 antibody - C-terminal (ab137799) at 1/1000 dilutionLane 1 : HeLa S3 whole cell lysateLane 2 : Hep G2 whole cell lysateLane 3 : MOLT4 whole cell lysateLane 4 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-FGFR3 Antibody (aa110-129) - LS-C313253 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
FGFR3 antibody. IHC(P): Rat Lung Tissue.
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