MYO6

Gene Symbol MYO6
Entrez Gene 4646
Alt Symbol DFNA22, DFNB37
Species Human
Gene Type protein-coding
Description myosin VI
Other Description myosin-VI|unconventional myosin-6|unconventional myosin-VI
Swissprots Q5TEM5 E1P540 Q9BZZ7 A6H8V4 Q9UEG2 Q9UM54 Q5TEM7 Q5TEM6
Accessions AAK00229 EAW48728 EAW48729 EAW48730 EAW48731 Q9UM54 AB002387 BAA20843 AK095294 BC012598 BC146764 AAI46765 BX647397 DB088907 L29145 AAA20908 U90236 AAC51654 XM_005248719 XP_005248776 XM_005248720 XP_005248777 XM_005248721 XP_005248778 XM_005248722 XP_005248779 XM_005248724 XP_005248781 XM_005248726 XP_005248783 NM_001300899 NP_001287828 NM_004999 NP_004990
Function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity). {ECO:0000250}.
Subcellular Location Isoform 4: Cytoplasmic vesicle, clathrin- coated vesicle membrane. Cell projection, ruffle membrane.
Tissue Specificity Expressed in most tissues examined including heart, brain, placenta, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in brain, pancreas, testis and small intestine. Also expressed in fetal brain and cochlea. Isoform 1 and isoform 2, containing the small insert, and isoform 4, containing neither insert, are expressed in unpolarized epithelial cells. {ECO:0000269|PubMed:9259267}.

Myosin VI (D5Y5A) Rabbit mAb - 13592 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5Y5A
Western blot analysis of extracts from various cell lines using Myosin VI (D5Y5A) Rabbit mAb.

Myosin VI Antibody - 9200 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Myosin VI (A-9) - sc-393558 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Myosin VI (A-9): sc-393558. Western blot analysis of Myosin VI expression in human liver tissue extract (A) and MCF7 (B) and MDA-MB-231 (C) whole cell lysates.

Myosin VI (G-6) - sc-398609 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Myosin VI (G-6): sc-398609. Western blot analysis of Myosin VI expression in DU 145 (A) and H4 (B) whole cell lysates and human liver (C) and rat liver (D) tissue extracts.

Myosin VI (H-215) - sc-50461 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Myosin VI (H-215): sc-50461. Western blot analysis of Myosin VI expression in H4 (A) and DU 145 (B) whole cell lysates.

Myosin VI (K-20) - sc-23568 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Myosin VI (K-20): sc-23568. Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx tissue showing cytoplasmic and nuclear staining of respiratory epithelial cells.

Myosin VI (MUD-19) - sc-58808 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-MYO6 antibody - ab11096 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab11096 staining Myo6 in Vero cell line from African green monkey kidney by ICC/IF (Immunocytochemistry/immunofluorescence).

Anti-MYO6 antibody - ab106288 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MYO6 antibody [MUD-19] - ab11095 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone MUD-19
All lanes : Anti-MYO6 antibody [MUD-19] (ab11095) at 1/250 dilutionLane 1 : Whole cell lysate prepared from human breast cell linesLane 2 : Whole cell lysate prepared from human breast cell linesLane 3 : Whole cell lysate prepared from human breast cell linesLane 4 : Whole cell lysate prepared from human breast cell linesSecondaryRabbit anti-mouse conjugated to HRPdeveloped using the ECL techniqueExposure time : 10 secondsImage courtesy of Dr Damian Yap by Abreview.

Anti-MYO6 antibody - C-terminal - ab170522 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of MCF7 cells, labeling MYO6 using ab170522 at a 1/10 dilution, followed by Alexa Fluor 488®-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclei (blue).

Anti-Myosin VI / MYO6 Antibody - LS-C144660 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Myosin VI / MYO6 Antibody (aa1173-1203, AP) - LS-C263880 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Myosin VI / MYO6 Antibody (aa1173-1203, APC) - LS-C263881 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Myosin VI / MYO6 Antibody (aa1173-1203, Biotin) - LS-C263882 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Myosin VI / MYO6 Antibody (aa1173-1203, PE) - LS-C263885 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Myosin VI / MYO6 Antibody (aa1173-1203, FITC) - LS-C263883 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Myosin VI / MYO6 Antibody (aa1173-1203) - LS-C323205 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Myosin VI / MYO6 Antibody (aa1173-1203, Azide-free, HRP) - LS-C263884 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Myosin VI / MYO6 Antibody (clone 2E12) - LS-C197736 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E12
MYO6 monoclonal antibody (M02), clone 2E12. Western Blot analysis of MYO6 expression in MCF-7.

Anti-Myosin VI / MYO6 Antibody - LS-C209179 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot of Rabbit anti-Myosin-6 antibody. Lane 1: SF9 cell lysate of truncated smooth myosin. Lane 2: Jurkat lysate. Lane 3: LnCap lysate. Lane 4: Recombinant myosin VI Load: 35 ug per lane for cell lysate. 50 ng of recombinant protein. Primary antibody: Myosin 6 antibody at 1:1000 for overnight at 4 degrees C. Secondary antibody: HRP rabbit secondary antibody at 1:40,000 for 60 min at RT. Block: 5% BLOTTO overnight at 4 degrees C. Predicted/Observed size: 150 kDa for Myo6.

Anti-Myosin VI / MYO6 Antibody (aa1173-1203) - LS-C164716 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MYO6 Antibody (C-term R1181) immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

MYO6 Antibody - NBP2-30003 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MYO6 Antibody [NBP2-30003] - MYO6 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MYO6 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.

MYO6 Antibody - NBP2-38254 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: MYO6 Antibody [NBP2-38254] - Staining of human kidney shows strong luminal membranous and cytoplasmic positivity in renal tubules.

MYO6 Antibody (2E12.) - H00004646-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E12.
Western Blot: MYO6 Antibody (2E12) [H00004646-M02] - MYO6 monoclonal antibody (M02), clone 2E12. Analysis of MYO6 expression in MCF-7.
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