| Gene Symbol | MYO6 |
|---|---|
| Entrez Gene | 4646 |
| Alt Symbol | DFNA22, DFNB37 |
| Species | Human |
| Gene Type | protein-coding |
| Description | myosin VI |
| Other Description | myosin-VI|unconventional myosin-6|unconventional myosin-VI |
| Swissprots | Q5TEM5 E1P540 Q9BZZ7 A6H8V4 Q9UEG2 Q9UM54 Q5TEM7 Q5TEM6 |
| Accessions | AAK00229 EAW48728 EAW48729 EAW48730 EAW48731 Q9UM54 AB002387 BAA20843 AK095294 BC012598 BC146764 AAI46765 BX647397 DB088907 L29145 AAA20908 U90236 AAC51654 XM_005248719 XP_005248776 XM_005248720 XP_005248777 XM_005248721 XP_005248778 XM_005248722 XP_005248779 XM_005248724 XP_005248781 XM_005248726 XP_005248783 NM_001300899 NP_001287828 NM_004999 NP_004990 |
| Function | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity). {ECO:0000250}. |
| Subcellular Location | Isoform 4: Cytoplasmic vesicle, clathrin- coated vesicle membrane. Cell projection, ruffle membrane. |
| Tissue Specificity | Expressed in most tissues examined including heart, brain, placenta, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in brain, pancreas, testis and small intestine. Also expressed in fetal brain and cochlea. Isoform 1 and isoform 2, containing the small insert, and isoform 4, containing neither insert, are expressed in unpolarized epithelial cells. {ECO:0000269|PubMed:9259267}. |
Myosin VI CRISPR/Cas9 KO Plasmid (h) - sc-401815 from Santa Cruz Biotechnology
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Myosin VI HDR Plasmid (h) - sc-401815-HDR from Santa Cruz Biotechnology
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Myosin VI Double Nickase Plasmid (h) - sc-401815-NIC from Santa Cruz Biotechnology
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Myosin VI Double Nickase Plasmid (h2) - sc-401815-NIC-2 from Santa Cruz Biotechnology
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Myosin VI CRISPR Activation Plasmid (h) - sc-401815-ACT from Santa Cruz Biotechnology
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Myosin VI CRISPR Activation Plasmid (h2) - sc-401815-ACT-2 from Santa Cruz Biotechnology
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Myosin VI Lentiviral Activation Particles (h) - sc-401815-LAC from Santa Cruz Biotechnology
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Myosin VI Lentiviral Activation Particles (h2) - sc-401815-LAC-2 from Santa Cruz Biotechnology
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Myosin VI siRNA (h) - sc-37133 from Santa Cruz Biotechnology
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Myosin VI shRNA Plasmid (h) - sc-37133-SH from Santa Cruz Biotechnology
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Myosin VI shRNA (h) Lentiviral Particles - sc-37133-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU079731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14864 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14864 from Sigma-Aldrich
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MYO6 siRNA (Human) - CRH3070 from Cohesion Biosciences
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shRNA set against Human MYO6 (NM_004999.3) - SHH348296 from Creative biogene
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Human MYO6 siRNA - orb263572 from Biorbyt
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MYO6 shRNA Plasmid (Human) - CHH3070 from Cohesion Biosciences
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MYO6 miRNA 3'UTR clone - MiUTR1H-06601 from Creative biogene
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