| Gene Symbol |
A1CF
|
| Entrez Gene |
29974
|
| Alt Symbol |
ACF, ACF64, ACF65, APOBEC1CF, ASP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
APOBEC1 complementation factor
|
| Other Description |
APOBEC-1 stimulating protein|apo-B RNA editing protein|apobec-1 complementation factor (ACF) (ASP)
|
| Swissprots |
Q9NZD3 A8K7G7 A1L4F2 Q9NXC9 Q5SZQ0 Q9NQ93 Q9NQ94 Q9NQX8 Q9NQX9 B7ZM14
|
| Accessions |
EAW54133 EAW54134 EAW54135 EAW54136 EAW54137 EAW54138 Q9NQ94 AF209192 AAF34824 AF271789 AAF76221 AF271790 AAF76222 AJ272078 CAB94754 AJ272079 CAB94755 AK000324 BAA91086 AK130022 AK291982 BAF84671 AK303801 BAG64755 BC022263 BC054873 AAH54873 BC130519 AAI30520 BC144194 BC144196 AAI44197 BG188383 CR749831 XM_005269718 XP_005269775 XM_005269720 XP_005269777 XM_011539729 XP_011538031 XM_011539730 XP_011538032 NM_001198818 NP_001185747 NM_001198819 NP_001185748 NM_001198820 NP_001185749 NM_014576 NP_055391 NM_138932 NP_620310 NM_138933 NP_620311
|
| Function |
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. {ECO:0000269|PubMed:10669759, ECO:0000269|PubMed:10781591, ECO:0000269|PubMed:12881431}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12881431}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12881431}. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed with highest levels in brain, liver, pancreas, colon and spleen. {ECO:0000269|PubMed:10669759}.
|