| Gene Symbol |
CNEP1R1
|
| Entrez Gene |
255919
|
| Alt Symbol |
C16orf69, NEP1-R1, TMEM188, TMP125
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CTD nuclear envelope phosphatase 1 regulatory subunit 1
|
| Other Description |
nuclear envelope phosphatase 1-regulatory subunit 1|nuclear envelope phosphatase-regulatory subunit 1|transmembrane protein 188
|
| Swissprots |
Q4G1A9 Q8N9A8 Q8NE06 Q5H9V0
|
| Accessions |
EAW82738 EAW82739 EAW82740 EAW82741 Q8N9A8 AF086322 AK095420 BAC04545 AK301610 BAG63096 AK307132 AK307309 BC022550 AAH22550 BC036683 AAH36683 BP259769 CR933600 CAI45924 FJ516381 ACL36922 HY011229 NM_001281789 NP_001268718 NM_153261 NP_694993 NR_104042 NR_104043
|
| Function |
Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. {ECO:0000269|PubMed:22134922}.
|
| Subcellular Location |
Nucleus membrane {ECO:0000269|PubMed:22134922}; Multi-pass membrane protein {ECO:0000269|PubMed:22134922}. Cytoplasm {ECO:0000269|PubMed:22134922}. Note=Filamentous pattern in the cytoplasm.
|
| Tissue Specificity |
Muscle specific with lower expression in other metabolic tissues. {ECO:0000269|PubMed:22134922}.
|
![Immunohistochemistry-Paraffin: TMEM188 Antibody [NBP1-88455] - Staining of human tonsil shows strong cytoplasmic positivity in subsets of cells outside germinal center.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_10/3503_TMEM188-Antibody-Immunohistochemistry-Paraffin-NBP1-88455-img0003.jpg)
![Immunocytochemistry/Immunofluorescence: TMEM188 Antibody [NBP2-58839] - Staining of human cell line U-2 OS shows localization to cytosol.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_10/854_TMEM188%2520Antibody-Immunocytochemistry-Immunofluorescence-NBP2-58839-img0001.jpg)