| Gene Symbol | ADAM17 |
|---|---|
| Entrez Gene | 6868 |
| Alt Symbol | ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE |
| Species | Human |
| Gene Type | protein-coding |
| Description | ADAM metallopeptidase domain 17 |
| Other Description | ADAM metallopeptidase domain 18|TNF-alpha convertase|TNF-alpha converting enzyme|disintegrin and metalloproteinase domain-containing protein 17|snake venom-like protease|tumor necrosis factor, alpha, converting enzyme |
| Swissprots | P78536 O60226 |
| Accessions | AAX93091 AAX93142 AAY14859 EAX00981 EAX00982 P78536 AK289829 BAF82518 AY422721 BC062687 AAH62687 BC136783 AAI36784 BC146658 AAI46659 BM725368 BQ186514 BX339672 CN258241 GQ402545 ACV30013 U69611 AAB51514 U69612 AAB53014 U86755 AAB51586 U92649 AAC39721 XM_011510375 XP_011508677 XM_011510376 XP_011508678 XM_011510377 XP_011508679 XM_011510378 XP_011508680 NM_003183 NP_003174 |
| Function | Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. {ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney. |
| Top Pathways | Notch signaling pathway, Alzheimer's disease, Epithelial cell signaling in Helicobacter pylori infection |