ADAM17

Gene Symbol	ADAM17
Entrez Gene	6868
Alt Symbol	ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE
Species	Human
Gene Type	protein-coding
Description	ADAM metallopeptidase domain 17
Other Description	ADAM metallopeptidase domain 18|TNF-alpha convertase|TNF-alpha converting enzyme|disintegrin and metalloproteinase domain-containing protein 17|snake venom-like protease|tumor necrosis factor, alpha, converting enzyme
Swissprots	P78536 O60226
Accessions	AAX93091 AAX93142 AAY14859 EAX00981 EAX00982 P78536 AK289829 BAF82518 AY422721 BC062687 AAH62687 BC136783 AAI36784 BC146658 AAI46659 BM725368 BQ186514 BX339672 CN258241 GQ402545 ACV30013 U69611 AAB51514 U69612 AAB53014 U86755 AAB51586 U92649 AAC39721 XM_011510375 XP_011508677 XM_011510376 XP_011508678 XM_011510377 XP_011508679 XM_011510378 XP_011508680 NM_003183 NP_003174
Function	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. {ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Top Pathways	Notch signaling pathway, Alzheimer's disease, Epithelial cell signaling in Helicobacter pylori infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ADAM17 protein fragment - ab138784 from Abcam Category Protein Prices $410.00 Sizes 20 µg Source Insect cells Species Human

ADAM17 peptide - ab41213 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ADAM17 peptide - ab41214 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ADAM17 peptide - ab41215 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ADAM17 peptide - ab41216 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

ADAM17 peptide - ab7881 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

ADAM17 peptide - ab94552 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human ADAM17 peptide - ab23216 from Abcam Category Peptide Species Human

Human ADAM17 protein fragment - ab114186 from Abcam Category Protein Source Wheat germ Species Human

ADAM17 / TACE Antibody Blocking Peptide - LS-E3721 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ADAM17 / TACE Antibody Blocking Peptide - LS-E3722 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ADAM17 / TACE Antibody Blocking Peptide - LS-E25330 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ADAM17 / TACE Antibody Blocking Peptide - LS-E29847 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TACE/ADAM17 Partial Recombinant Protein - H00006868-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TACE/ADAM17 Blocking Peptide - NBP1-77044PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TACE/ADAM17 Peptide - P0488 from Novus Biologicals Category Peptide Species Human

TACE/ADAM17 Peptide - P0487 from Novus Biologicals Category Peptide Species Human

ADAM17-Antibody-C-term-Blocking-Peptide - BP1492b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ADAM17-Antibody-N-term-Blocking-Peptide - BP1492a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Tumor-Necrosis-Factor-a-Converting-Enzyme-TACE-807-823-human - SP2161b from Abgent, a WuXi AppTec company Category Peptide Prices $375.00 Sizes 5 mg Species Human

Tumor-Necrosis-Factor-a-Converting-Enzyme-TACE-807-823-human - SP2161a from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg Species Human

ADAM17 blocking peptide - GTX89760-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Recombinant Human TACE/ADAM17, CF - 930-ADB-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Arg215-Asn671, with a C-terminal 6-His tag

Recombinant Human TACE/ADAM17 Cytosolic Western Blot Std - WBC030 from R&D Systems Category Protein Prices $109.00 Sizes 1 vial Species Human

CD156b Blocking Peptide - abx063327 from Abbexa Category Peptide Species Human, Mouse, Rat

Search more