HIF3A

Gene Symbol HIF3A
Entrez Gene 64344
Alt Symbol HIF-3A, IPAS, MOP7, PASD7, bHLHe17
Species Human
Gene Type protein-coding
Description hypoxia inducible factor 3, alpha subunit
Other Description HIF3-alpha-1|PAS domain-containing protein 7|basic-helix-loop-helix-PAS protein MOP7|class E basic helix-loop-helix protein 17|hypoxia-inducible factor 3-alpha|inhibitory PAS domain protein|member of PAS protein 7
Swissprots B4DNA2 Q9Y2N7 Q9HAI2 Q96K34 Q9H7Z9 B0M185 Q58A43 Q66K72 I6L988 Q8WXA1
Accessions AAD22667 AAD22668 EAW57408 EAW57409 EAW57410 EAW57411 EAW57412 EAW57413 EAW57414 Q9Y2N7 AB054067 BAB69689 AB118749 BAD93355 AB295039 BAG07185 AF079154 AAC99397 AF463492 AAL69947 AK021421 BAB13819 AK021653 BAB13865 AK021881 AK024095 BAB14824 AK027725 BAB55324 AK297828 BAG60164 AK299699 BAG61601 AK304747 BAG65505 AK314680 BAG37233 AL541807 AU143858 BC026308 AAH26308 BC080551 AAH80551 BE250295 BE250712 BI772109 BM971722 BQ706970 CA437428 CF593418 DA559979 DA562618 DB176660 DC423791 DN989983 DR001068 XM_005259152 XP_005259209 XM_005259153 XP_005259210 XM_005259154 XP_005259211 XM_005259155 XP_005259212 XM_005259156 XP_005259213 XM_006723325 XP_006723388 XR_935849 NM_022462 NP_071907 NM_152794 NP_690007 NM_152795 NP_690008 NM_152796 NP_690009
Function Isoform 5: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. {ECO:0000269|PubMed:21069422}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16775626, ECO:0000269|PubMed:19694616}. Cytoplasm {ECO:0000269|PubMed:19694616}. Nucleus speckle {ECO:0000250|UniProtKB:Q0VBL6}. Mitochondrion {ECO:0000250|UniProtKB:Q0VBL6}. Note=In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes with BAD in the cytoplasm. Colocalizes with EPAS1 and HIF1A in the nucleus and speckles (By similarity). Localized in the cytoplasm and nuclei under normoxia, but increased in the nucleus under hypoxic conditions (PubMed:19694616). Colocalized with HIF1A in kidney tumors (PubMed:19694616). {ECO:0000250|UniProtKB:Q0VBL6, ECO:0000250|UniProtKB:Q9JHS2, ECO:0000269|PubMed:19694616}.
Tissue Specificity Expressed in vascular cells (at protein level) (PubMed:21069422). Expressed in kidney (PubMed:11573933, PubMed:19694616). Expressed in lung epithelial cells (PubMed:16775626). Expressed in endothelial cells (venous and arterial cells from umbilical cord and aortic endothelial cells) and in vascular smooth muscle cells (aorta) (PubMed:21069422). Strongly expressed in the heart, placenta, and skeletal muscle, whereas a weak expression profile was found in the lung, liver, and kidney (PubMed:12538644). Expressed weakly in cell renal cell carcinoma (CC-RCC) compared to normal renal cells (PubMed:16126907). Expression is down-regulated in numerous kidney tumor cells compared to non tumor kidney tissues (PubMed:16126907). Isoform 2 is expressed in heart, placenta, lung, liver, skeletal muscle and pancreas and in numerous cancer cell lines (PubMed:20416395). Isoform 3 and isoform 4 are weakly expressed in heart, placenta, lung, liver, skeletal muscle and pancreas (PubMed:20416395). Isoform 4

HIF-3α (E-8) - sc-390933 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HIF-3α (E-8): sc-390933. Western blot analysis of HIF-3α expression in non-transfected (A) and human HIF-3α transfected (B) CMV whole cell lysates.

HIF-3α (D-7) - sc-390769 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HIF-3α (D-7): sc-390769. Western blot analysis of HIF-3α expression in non-transfected (A) and human HIF3 transfected (B) CMV whole cell lysates.

HIF-3α (H-170) - sc-28707 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HIF-3α (H-170): sc-28707. Western blot analysis of HIF-3α expression in mouse liver (A) and rat liver (B) tissue extracts.

HIF-3α (T-15) - sc-32142 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HIF-30α (T-15): sc-32142. Western blot analysis of human recombinant HIF-3α fusion protein.

HIF-3α (V-15) - sc-32141 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HIF-3α (V-15): sc-32141. Western blot analysis of human recombinant HIF-3α fusion protein.

HIF-3α (C-18) - sc-32144 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HIF-3α (C-18): sc-32144. Western blot analysis of human recombinant HIF-3α fusion protein.

HIF-3α (H-15) - sc-32139 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-HIF3 alpha antibody - ab10134 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab10134 stained human HeLa cells. The cells were methanol fixed (5 min) and incubated with the antibody (ab10134, 5µg/ml) for 1h at room temperature. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Image-iTTM FX Signal Enhancer was used as the primary blocking agent, 5% BSA (in TBS-T) was used for all other blocking steps. DAPI was used to stain the cell nuclei (blue). Alexa Fluor® 594 WGA was used to label plasma membranes (red).

Anti-HIF3 alpha antibody - ab134714 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HIF3 alpha antibody (ab134714) at 1/500 dilution + Rat brain cell extract at 30 µg

Anti-HIF3 alpha antibody - ab176464 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HIF3 alpha antibody (ab176464) at 0.1 µg/ml + Rat brain tissue lysate

Anti-HIF3 alpha antibody - ab107127 from Abcam

Prices $359.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-HIF3 alpha antibody (ab107127) at 1/100 dilution + HepG2 cell line lysates at 35 µg

Anti-HIF3 alpha antibody [2D2] - ab139280 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D2
All lanes : Anti-HIF3 alpha antibody [2D2] (ab139280) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control Lane 2 : HEK293T cells transfected with pCMV6-ENTRY HIF3 alpha Lysates/proteins at 5 µg per lane.

Anti-HIF3 alpha antibody [4C2] - ab170152 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4C2
Immunohistochemical analysis of paraffin-embedded Human lymph node tissue labeling HIF3 alpha with ab170152 at 1/150 dilution.

Anti-HIF3A / HIF3-Alpha Antibody (aa581-592) - LS-C7476 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HIF3A / HIF3-Alpha Antibody (Internal) - LS-C123800 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HIF3A / HIF3-Alpha Antibody (N-Terminus) - LS-C124958 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HIF3A / HIF3-Alpha Antibody (N-Terminus, DY650) - LS-C140960 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HIF3A / HIF3-Alpha Antibody (N-Terminus, Biotin) - LS-C140959 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HIF3A / HIF3-Alpha Antibody (N-Terminus, DY488) - LS-C140961 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HIF3A / HIF3-Alpha Antibody (N-Terminus, HRP) - LS-C140962 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HIF3A / HIF3-Alpha Antibody (N-Terminus, DY550) - LS-C140963 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HIF3A / HIF3-Alpha Antibody (Internal, Biotin) - LS-C141067 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HIF3A / HIF3-Alpha Antibody (Internal, DY650) - LS-C141068 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HIF3A / HIF3-Alpha Antibody (Internal, DY488) - LS-C141069 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HIF3A / HIF3-Alpha Antibody (Internal, HRP) - LS-C141070 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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