| Gene Symbol |
HIF3A
|
| Entrez Gene |
64344
|
| Alt Symbol |
HIF-3A, IPAS, MOP7, PASD7, bHLHe17
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hypoxia inducible factor 3, alpha subunit
|
| Other Description |
HIF3-alpha-1|PAS domain-containing protein 7|basic-helix-loop-helix-PAS protein MOP7|class E basic helix-loop-helix protein 17|hypoxia-inducible factor 3-alpha|inhibitory PAS domain protein|member of PAS protein 7
|
| Swissprots |
B4DNA2 Q9Y2N7 Q9HAI2 Q96K34 Q9H7Z9 B0M185 Q58A43 Q66K72 I6L988 Q8WXA1
|
| Accessions |
AAD22667 AAD22668 EAW57408 EAW57409 EAW57410 EAW57411 EAW57412 EAW57413 EAW57414 Q9Y2N7 AB054067 BAB69689 AB118749 BAD93355 AB295039 BAG07185 AF079154 AAC99397 AF463492 AAL69947 AK021421 BAB13819 AK021653 BAB13865 AK021881 AK024095 BAB14824 AK027725 BAB55324 AK297828 BAG60164 AK299699 BAG61601 AK304747 BAG65505 AK314680 BAG37233 AL541807 AU143858 BC026308 AAH26308 BC080551 AAH80551 BE250295 BE250712 BI772109 BM971722 BQ706970 CA437428 CF593418 DA559979 DA562618 DB176660 DC423791 DN989983 DR001068 XM_005259152 XP_005259209 XM_005259153 XP_005259210 XM_005259154 XP_005259211 XM_005259155 XP_005259212 XM_005259156 XP_005259213 XM_006723325 XP_006723388 XR_935849 NM_022462 NP_071907 NM_152794 NP_690007 NM_152795 NP_690008 NM_152796 NP_690009
|
| Function |
Isoform 5: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. {ECO:0000269|PubMed:21069422}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16775626, ECO:0000269|PubMed:19694616}. Cytoplasm {ECO:0000269|PubMed:19694616}. Nucleus speckle {ECO:0000250|UniProtKB:Q0VBL6}. Mitochondrion {ECO:0000250|UniProtKB:Q0VBL6}. Note=In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes with BAD in the cytoplasm. Colocalizes with EPAS1 and HIF1A in the nucleus and speckles (By similarity). Localized in the cytoplasm and nuclei under normoxia, but increased in the nucleus under hypoxic conditions (PubMed:19694616). Colocalized with HIF1A in kidney tumors (PubMed:19694616). {ECO:0000250|UniProtKB:Q0VBL6, ECO:0000250|UniProtKB:Q9JHS2, ECO:0000269|PubMed:19694616}.
|
| Tissue Specificity |
Expressed in vascular cells (at protein level) (PubMed:21069422). Expressed in kidney (PubMed:11573933, PubMed:19694616). Expressed in lung epithelial cells (PubMed:16775626). Expressed in endothelial cells (venous and arterial cells from umbilical cord and aortic endothelial cells) and in vascular smooth muscle cells (aorta) (PubMed:21069422). Strongly expressed in the heart, placenta, and skeletal muscle, whereas a weak expression profile was found in the lung, liver, and kidney (PubMed:12538644). Expressed weakly in cell renal cell carcinoma (CC-RCC) compared to normal renal cells (PubMed:16126907). Expression is down-regulated in numerous kidney tumor cells compared to non tumor kidney tissues (PubMed:16126907). Isoform 2 is expressed in heart, placenta, lung, liver, skeletal muscle and pancreas and in numerous cancer cell lines (PubMed:20416395). Isoform 3 and isoform 4 are weakly expressed in heart, placenta, lung, liver, skeletal muscle and pancreas (PubMed:20416395). Isoform 4
|