| Gene Symbol |
BTN3A1
|
| Entrez Gene |
11119
|
| Alt Symbol |
BT3.1, BTF5, BTN3.1, CD277
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
butyrophilin, subfamily 3, member A1
|
| Other Description |
butyrophilin subfamily 3 member A1|dJ45P21.3 (butyrophilin, subfamily 3, member A1)
|
| Swissprots |
B4DIQ1 E9PHG8 Q53F15 E9PGB4 B4DRM2 Q0P515 O00481 A2A278 Q99420 A8K2C8 Q147X5 Q9HCY1
|
| Accessions |
EAW55566 EAW55567 O00481 AA977088 AK223474 BAD97194 AK290193 BAF82882 AK291162 BAF83851 AK295720 BAG58563 AK298652 BAG60824 AK299327 BAG61334 AK311233 BC065567 BC118586 AAI18587 BC121800 AAI21801 BG744194 BM147268 BM542639 BU178206 BU617041 CA309315 CB148209 CD110416 DA044176 DC417480 T86577 U90552 AAB53430 Y07827 CAA69164 XM_005248833 XP_005248890 XM_005248834 XP_005248891 XM_006714983 XP_006715046 XM_011514272 XP_011512574 XM_011514273 XP_011512575 XR_926039 NM_001145008 NP_001138480 NM_001145009 NP_001138481 NM_007048 NP_008979 NM_194441 NP_919423
|
| Function |
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. {ECO:0000269|PubMed:21113407, ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497, ECO:0000269|PubMed:22846996}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:21113407, ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}; Single- pass type I membrane protein {ECO:0000269|PubMed:21113407, ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}.
|
| Tissue Specificity |
Detected on T-cells, natural killer cells, dendritic cells and macrophages (at protein level). Ubiquitous. Highly expressed in heart, pancreas and lung, Moderately expressed in placenta, liver and muscle. {ECO:0000269|PubMed:20610803, ECO:0000269|PubMed:21113407, ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:9149941}.
|
![Western Blot: BTN3A1 Overexpression Lysate (Adult Normal) [NBP2-07539] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BTN3A1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2909_BTN3A1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07539-img0001.jpg)