| Gene Symbol |
MAN1C1
|
| Entrez Gene |
57134
|
| Alt Symbol |
HMIC, MAN1A3, MAN1C, pp6318
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mannosidase, alpha, class 1C, member 1
|
| Other Description |
1,2-alpha-mannosidase IC|mannosyl-oligosaccharide 1,2-alpha-mannosidase IC|processing alpha-1,2-mannosidase IC
|
| Swissprots |
B2RNP2 A6NNE2 Q9NR34 Q9Y545
|
| Accessions |
EAX07870 EAX07871 Q9NR34 AB209275 BAD92512 AF261655 AAF97058 AK128560 AL049274 BC038959 BC137017 AAI37018 DA068812 XM_005245945 XP_005246002 XM_011541805 XP_011540107 NM_001289010 NP_001275939 NM_020379 NP_065112
|
| Function |
Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.
|
| Subcellular Location |
Golgi apparatus membrane; Single-pass type II membrane protein.
|
| Tissue Specificity |
Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta.
|
| Top Pathways |
N-Glycan biosynthesis, Protein processing in endoplasmic reticulum
|