Gene Symbol | MAN1C1 |
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Entrez Gene | 57134 |
Alt Symbol | HMIC, MAN1A3, MAN1C, pp6318 |
Species | Human |
Gene Type | protein-coding |
Description | mannosidase, alpha, class 1C, member 1 |
Other Description | 1,2-alpha-mannosidase IC|mannosyl-oligosaccharide 1,2-alpha-mannosidase IC|processing alpha-1,2-mannosidase IC |
Swissprots | B2RNP2 A6NNE2 Q9NR34 Q9Y545 |
Accessions | EAX07870 EAX07871 Q9NR34 AB209275 BAD92512 AF261655 AAF97058 AK128560 AL049274 BC038959 BC137017 AAI37018 DA068812 XM_005245945 XP_005246002 XM_011541805 XP_011540107 NM_001289010 NP_001275939 NM_020379 NP_065112 |
Function | Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc. |
Subcellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. |
Tissue Specificity | Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta. |
Top Pathways | N-Glycan biosynthesis, Protein processing in endoplasmic reticulum |
MAN1C1 CRISPR/Cas9 KO Plasmid (h) - sc-412760 from Santa Cruz Biotechnology
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MAN1C1 HDR Plasmid (h) - sc-412760-HDR from Santa Cruz Biotechnology
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MAN1C1 Double Nickase Plasmid (h) - sc-412760-NIC from Santa Cruz Biotechnology
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MAN1C1 Double Nickase Plasmid (h2) - sc-412760-NIC-2 from Santa Cruz Biotechnology
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MAN1C1 CRISPR Activation Plasmid (h) - sc-412760-ACT from Santa Cruz Biotechnology
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MAN1C1 CRISPR Activation Plasmid (h2) - sc-412760-ACT-2 from Santa Cruz Biotechnology
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MAN1C1 Lentiviral Activation Particles (h) - sc-412760-LAC from Santa Cruz Biotechnology
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MAN1C1 Lentiviral Activation Particles (h2) - sc-412760-LAC-2 from Santa Cruz Biotechnology
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MAN1C1 siRNA (h) - sc-88747 from Santa Cruz Biotechnology
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MAN1C1 shRNA Plasmid (h) - sc-88747-SH from Santa Cruz Biotechnology
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MAN1C1 shRNA (h) Lentiviral Particles - sc-88747-V from Santa Cruz Biotechnology
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MAN1C1 RNAi - H00057134-R01 from Novus Biologicals
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MISSION® esiRNA - EHU095571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12964 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12964 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08184 from Sigma-Aldrich
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MAN1C1 siRNA (Human) - CRJ1347 from Cohesion Biosciences
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shRNA set against Human MAN1C1 (NM_020379.2) - SHH337287 from Creative biogene
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Human MAN1C1 siRNA - orb271848 from Biorbyt
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MAN1C1 shRNA Plasmid (Human) - CHJ1347 from Cohesion Biosciences
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MAN1C1 miRNA 3'UTR clone - MiUTR1H-06035 from Creative biogene
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