| Gene Symbol |
Trim30a
|
| Entrez Gene |
20128
|
| Alt Symbol |
Rpt-1, Rpt1, Trim30
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif-containing 30A
|
| Other Description |
down regulatory protein of interleukin-2 receptor|regulatory protein, T lymphocyte 1|tripartite motif protein 30|tripartite motif-containing 30|tripartite motif-containing protein 30|tripartite motif-containing protein 30A
|
| Swissprots |
Q99PQ7 Q99PQ9 Q99PQ8 Q3UV85 Q99K55 Q3UZ29 P15533
|
| Accessions |
AAG53470 EDL16725 EDL16726 P15533 AF220014 AAG53468 AF220015 AAG53469 AK089726 AK134144 BAE22032 AK137506 BAE23387 AK137592 AK138249 BAE23595 BC005447 AAH05447 DV644722 J03776 AAA40073 XM_006507471 XP_006507534 NM_009099 NP_033125
|
| Function |
Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses. {ECO:0000269|PubMed:18345001, ECO:0000269|PubMed:19147168, ECO:0000269|PubMed:21048113}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Highly expressed in spleen and lymph nodes (at protein level). {ECO:0000269|PubMed:18345001}.
|