Trim30a

Gene Symbol Trim30a
Entrez Gene 20128
Alt Symbol Rpt-1, Rpt1, Trim30
Species Mouse
Gene Type protein-coding
Description tripartite motif-containing 30A
Other Description down regulatory protein of interleukin-2 receptor|regulatory protein, T lymphocyte 1|tripartite motif protein 30|tripartite motif-containing 30|tripartite motif-containing protein 30|tripartite motif-containing protein 30A
Swissprots Q99PQ7 Q99PQ9 Q99PQ8 Q3UV85 Q99K55 Q3UZ29 P15533
Accessions AAG53470 EDL16725 EDL16726 P15533 AF220014 AAG53468 AF220015 AAG53469 AK089726 AK134144 BAE22032 AK137506 BAE23387 AK137592 AK138249 BAE23595 BC005447 AAH05447 DV644722 J03776 AAA40073 XM_006507471 XP_006507534 NM_009099 NP_033125
Function Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses. {ECO:0000269|PubMed:18345001, ECO:0000269|PubMed:19147168, ECO:0000269|PubMed:21048113}.
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Highly expressed in spleen and lymph nodes (at protein level). {ECO:0000269|PubMed:18345001}.

TRIM30A CRISPR/Cas9 KO Plasmid (m) - sc-422753 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

TRIM30A HDR Plasmid (m) - sc-422753-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

TRIM30A Double Nickase Plasmid (m) - sc-422753-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

TRIM30A Double Nickase Plasmid (m2) - sc-422753-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

TRIM30A CRISPR Activation Plasmid (m) - sc-422753-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

TRIM30A CRISPR Activation Plasmid (m2) - sc-422753-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

TRIM30A Lentiviral Activation Particles (m) - sc-422753-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

TRIM30A Lentiviral Activation Particles (m2) - sc-422753-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

TRIM30A siRNA (m) - sc-154645 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

TRIM30A shRNA Plasmid (m) - sc-154645-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

TRIM30A shRNA (m) Lentiviral Particles - sc-154645-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU199021 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN43442 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43442 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TRIM30A siRNA (Mouse) - CRM3552 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

TRIM30A - MBS8203952 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse Trim30a (NM_009099.2) - SHH434588 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Trim30(NM_009099.2) - SHR198354 from Creative biogene

Category siRNA
Species Reactivities Mouse

TRIM30A shRNA Plasmid (Mouse) - CHM3552 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

TRIM30A miRNA 3'UTR clone - MiUTR1M-12132 from Creative biogene

Species Reactivities Mouse
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