| Gene Symbol |
MS4A2
|
| Entrez Gene |
2206
|
| Alt Symbol |
APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
membrane-spanning 4-domains, subfamily A, member 2
|
| Other Description |
Fc fragment of IgE, high affinity I, receptor for; beta polypeptide|High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain)|high affinity IgE receptor beta subunit|high affinity immunoglobulin epsilon receptor subunit beta|igE Fc receptor subunit beta|immunoglobulin E receptor, high affinity, beta polypeptide
|
| Swissprots |
Q54A81 Q01362
|
| Accessions |
AAA60269 BAB17032 BAC66486 EAW73865 Q01362 AK304487 BAG65297 AK310142 BC074800 AAH74800 BC074843 AAH74843 D10583 BAA01440 DA972757 GD138492 JF411082 AEA50999 X66187 CAA46955 XM_005273846 XP_005273903 XM_011544850 XP_011543152 NM_000139 NP_000130 NM_001256916 NP_001243845 NM_001142303
|
| Function |
High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Found on the surface of mast cells and basophils.
|
| Top Pathways |
Fc epsilon RI signaling pathway, Asthma, Sphingolipid signaling pathway
|