| Gene Symbol |
CPSF1
|
| Entrez Gene |
29894
|
| Alt Symbol |
CPSF160, HSU37012, P/cl.18
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cleavage and polyadenylation specific factor 1, 160kDa
|
| Other Description |
CPSF 160 kDa subunit|cleavage and polyadenylation specificity factor 160 kDa subunit|cleavage and polyadenylation specificity factor subunit 1|polyadenylation specificity factor
|
| Swissprots |
Q10570 Q96AF0
|
| Accessions |
EAW82106 EAW82107 EAW82108 EAW82109 EAW82110 Q10570 AB046744 BAB21613 AK293601 BAG57065 BC009954 BC017232 AAH17232 BC028197 CD299980 DQ893479 ABM84405 DQ896356 ABM87355 U37012 AAC50293 XM_006716548 XP_006716611 XM_006716549 XP_006716612 XM_006716550 XP_006716613 XM_011516997 XP_011515299 XM_011516998 XP_011515300 XM_011516999 XP_011515301 NM_013291 NP_037423
|
| Function |
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. {ECO:0000269|PubMed:14749727}.
|
| Subcellular Location |
Nucleus, nucleoplasm.
|
| Top Pathways |
mRNA surveillance pathway
|