Gene Symbol | EAF2 |
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Entrez Gene | 55840 |
Alt Symbol | BM040, TRAITS, U19 |
Species | Human |
Gene Type | protein-coding |
Description | ELL associated factor 2 |
Other Description | ELL-associated factor 2|testosterone-regulated apoptosis inducer and tumor suppressor protein |
Swissprots | Q9NZ82 Q96CJ1 |
Accessions | EAW79497 EAW79498 Q96CJ1 AF217516 AAF67627 AF517829 AAO63811 AK301560 BAG63055 AY049020 AAL12223 BC014209 AAH14209 BC014589 BU941228 DQ892648 ABM83574 DQ895887 ABM86813 XM_005247618 XP_005247675 XM_005247620 XP_005247677 XM_011512985 XP_011511287 XM_011512986 XP_011511288 NM_018456 NP_060926 |
Function | Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo. {ECO:0000250, ECO:0000269|PubMed:12446457, ECO:0000269|PubMed:12907652, ECO:0000269|PubMed:16006523}. |
Subcellular Location | Nucleus speckle {ECO:0000269|PubMed:12446457, ECO:0000269|PubMed:12907652}. Note=Colocalizes with ELL to nuclear speckles. |
Tissue Specificity | Expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine, colon, adrenal, bone marrow, lymph node, spinal gland, stomach, thyroid, trachea, thymus, liver and leukocytes. {ECO:0000269|PubMed:12446457, ECO:0000269|PubMed:12907652}. |
EAF2 CRISPR/Cas9 KO Plasmid (h) - sc-407180 from Santa Cruz Biotechnology
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EAF2 HDR Plasmid (h) - sc-407180-HDR from Santa Cruz Biotechnology
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EAF2 Double Nickase Plasmid (h) - sc-407180-NIC from Santa Cruz Biotechnology
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EAF2 Double Nickase Plasmid (h2) - sc-407180-NIC-2 from Santa Cruz Biotechnology
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EAF2 CRISPR Activation Plasmid (h) - sc-407180-ACT from Santa Cruz Biotechnology
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EAF2 CRISPR Activation Plasmid (h2) - sc-407180-ACT-2 from Santa Cruz Biotechnology
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EAF2 Lentiviral Activation Particles (h) - sc-407180-LAC from Santa Cruz Biotechnology
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EAF2 Lentiviral Activation Particles (h2) - sc-407180-LAC-2 from Santa Cruz Biotechnology
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EAF2 siRNA (h) - sc-62251 from Santa Cruz Biotechnology
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EAF2 shRNA Plasmid (h) - sc-62251-SH from Santa Cruz Biotechnology
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EAF2 shRNA (h) Lentiviral Particles - sc-62251-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU008031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7613 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7613 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02494 from Sigma-Aldrich
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EAF2 siRNA (Human) - CRJ0962 from Cohesion Biosciences
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EAF2 - MBS8207405 from MyBioSource
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shRNA set against Human EAF2 (NM_018456.4) - SHH282633 from Creative biogene
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shRNA set against Human EAF2(NM_018456.4) - SHH022333 from Creative biogene
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EAF2 shRNA Plasmid (Human) - CHJ0962 from Cohesion Biosciences
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EAF2 miRNA 3'UTR clone - MiUTR1H-03082 from Creative biogene
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