| Gene Symbol |
KIDINS220
|
| Entrez Gene |
57498
|
| Alt Symbol |
ARMS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kinase D-interacting substrate, 220kDa
|
| Other Description |
ankyrin repeat-rich membrane spanning|ankyrin repeat-rich membrane-spanning protein|kinase D-interacting substrate of 220 kDa|truncated KIDINS220
|
| Swissprots |
A1L4N4 Q9UF42 Q9NT37 Q9H889 Q6MZU2 Q9H9E4 Q9ULH0 Q4VC08
|
| Accessions |
CAD42170 EAX01014 EAX01015 EAX01016 Q9ULH0 AB033076 BAA86564 AB621829 BAK64164 AI088931 AK022873 BAB14285 AK023926 BAB14728 AK025528 AK057125 AK074254 AK294464 BAG57695 AK294832 BAG57942 AK295358 BAG58324 AK296459 BAG59106 AL133620 CAB63746 AL137553 CAB70807 BC039409 BC094714 AAH94714 BC130610 AAI30611 BX538189 CAD98059 BX640878 CAE45935 DA507846 KJ812119 AIJ27493 KJ812120 AIJ27494 KJ812121 AIJ27495 NM_020738 NP_065789
|
| Function |
Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)- induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress- induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Late endosome {ECO:0000250}. Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation.
|
| Tissue Specificity |
Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines. {ECO:0000269|PubMed:18089783}.
|
| Top Pathways |
Neurotrophin signaling pathway
|
