KIDINS220

Gene Symbol KIDINS220
Entrez Gene 57498
Alt Symbol ARMS
Species Human
Gene Type protein-coding
Description kinase D-interacting substrate, 220kDa
Other Description ankyrin repeat-rich membrane spanning|ankyrin repeat-rich membrane-spanning protein|kinase D-interacting substrate of 220 kDa|truncated KIDINS220
Swissprots A1L4N4 Q9UF42 Q9NT37 Q9H889 Q6MZU2 Q9H9E4 Q9ULH0 Q4VC08
Accessions CAD42170 EAX01014 EAX01015 EAX01016 Q9ULH0 AB033076 BAA86564 AB621829 BAK64164 AI088931 AK022873 BAB14285 AK023926 BAB14728 AK025528 AK057125 AK074254 AK294464 BAG57695 AK294832 BAG57942 AK295358 BAG58324 AK296459 BAG59106 AL133620 CAB63746 AL137553 CAB70807 BC039409 BC094714 AAH94714 BC130610 AAI30611 BX538189 CAD98059 BX640878 CAE45935 DA507846 KJ812119 AIJ27493 KJ812120 AIJ27494 KJ812121 AIJ27495 NM_020738 NP_065789
Function Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)- induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress- induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Late endosome {ECO:0000250}. Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation.
Tissue Specificity Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines. {ECO:0000269|PubMed:18089783}.
Top Pathways Neurotrophin signaling pathway

ARMS (26) - sc-136462 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ARMS (26): sc-136462. Western blot analysis of ARMS expression in rat brain tissue extract.

ARMS (L-19) - sc-324827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ARMS (P-20) - sc-324828 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ARMS (P-20): sc-324828. Western blot analysis of ARMS expression in Ramos whole cell lysate.

ARMS (R-300) - sc-48738 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ARMS (R-300): sc-48738. Western blot analysis of ARMS expression in K-562 (A), HeLa (B) and Raji (C) whole cell lysates and rat brain tissue extract (D).

ARMS (C-20) - sc-324829 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Kidins220 (phospho S919) antibody - ab34792 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Kidins220 antibody - ab34790 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab34790 stained PC12 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab34790, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Kidins220 antibody - ab97345 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Kidins220 antibody (ab97345) at 1/1000 dilutionLane 1 : H1299 whole cell lysateLane 2 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Kidins220 antibody - ab124194 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Kidins220 antibody (ab124194) at 1/100 dilution + K562 cell line lysates at 35 µg

Anti-KIDINS220 / ARMS Antibody (aa1747-1762) - LS-C40662 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KIDINS220 / ARMS Antibody (phospho-Ser919) - LS-C40676 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KIDINS220 / ARMS Antibody (aa1518-1547, AP) - LS-C207148 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KIDINS220 / ARMS Antibody (aa1518-1547, APC) - LS-C207149 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KIDINS220 / ARMS Antibody (aa1518-1547, FITC) - LS-C207153 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KIDINS220 / ARMS Antibody (aa1518-1547, PE) - LS-C207155 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KIDINS220 / ARMS Antibody (aa1518-1547, Biotin) - LS-C207152 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KIDINS220 / ARMS Antibody (aa1518-1547, Azide-free, HRP) - LS-C207154 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KIDINS220 / ARMS Antibody (aa1721-1771) - LS-C289709 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KIDINS220 / ARMS Antibody (aa1400-1450) - LS-C289708 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KIDINS220 / ARMS Antibody (aa1517-1547) - LS-C322444 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KIDINS220 / ARMS Antibody (aa1706-1771) - LS-C186158 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded SW480 xenograft using KIDINS220 antibody at 1:500 dilution.

Anti-KIDINS220 / ARMS Antibody (aa1518-1547) - LS-C165510 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
KIDINS220 Antibody western blot of K562 cell line lysates (35 ug/lane). The KIDINS220 antibody detected the KIDINS220 protein (arrow).

Anti-KIDINS220 / ARMS Antibody - LS-C332594 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using KIDINS220 antibody.

KIDINS220 Antibody - NBP1-31216 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: KIDINS220 Antibody [NBP1-31216] - Sample(30 ug whole cell lysate) A:H1299 B:Raji 5% SDS PAGE, antibody diluted at 1:1000.

KIDINS220 Antibody - NBP1-50035 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: KIDINS220 Antibody [NBP1-50035] - Detection of Human ARMS by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-ARMS antibod used for IP at 6 mcg/mg lysate. ARMS was also immunoprecipitated by rabbit anti-ARMS antibody which recognizes an upstream epitope. For blotting immunoprecipitated ARMS was used at 1 mcg/ml, and the ReliaBLOT Reagents and Procedures were incorporated. Detection: Chemiluminescence with an exposure time of 30 seconds.
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