NR3C2

Gene Symbol	NR3C2
Entrez Gene	4306
Alt Symbol	MCR, MLR, MR, NR3C2VIT
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 3, group C, member 2
Other Description	aldosterone receptor|mineralocorticoid receptor|mineralocorticoid receptor 1|mineralocorticoid receptor delta
Swissprots	B0ZBF5 B0ZBF7 Q96KQ9 P08235 Q2NKL1 Q96KQ8
Accessions	AAY41033 ACA05923 ACA05924 ACA05926 ACS13715 ACS13716 ACS13718 EAX05008 P08235 AB209056 BAD92293 AJ315514 CAC67405 AJ315515 CAC67406 AK123047 AK304318 BAG65170 BC111758 AAI11759 BQ184536 DB061545 DB232659 M16801 AAA59571 XM_011531975 XP_011530277 XM_011531976 XP_011530278 XM_011531977 XP_011530279 XM_011531978 XP_011530280 NM_000901 NP_000892 NM_001166104 NP_001159576
Function	Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}.
Subcellular Location	Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
Tissue Specificity	Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes. {ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:9141514}.
Top Pathways	Aldosterone-regulated sodium reabsorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Mineralocorticoid Receptor peptide - ab87358 from Abcam Category Peptide Species Human

Human Mineralocorticoid Receptor peptide - ab74464 from Abcam Category Peptide

Human Mineralocorticoid Receptor protein fragment - ab152533 from Abcam Category Protein Source Wheat germ Species Human

Mineralocorticoid Receptor Antibody Blocking Peptide - LS-E4822 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Mineralocorticoid Receptor Antibody Blocking Peptide - LS-E10793 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Mineralocorticoid Receptor Antibody Blocking Peptide - LS-E10794 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Mineralocorticoid R/NR3C2 Protein - H00004306-Q01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

NR3C2-Antibody-Center-Blocking-Peptide - BP17202c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NR3C2 Blocking Peptide - 33R-8142 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Mineralocorticoid receptor - H00004306-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Mineralocorticoid receptor - H00004306-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NR3C2 fusion protein - ag16410 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Mineralocorticoid receptor LBD/Hsp90 complex, GST-tagged - NR3C2-105H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human NR3C2 - NR3C2-504H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Mineralocorticoid Receptor (MR) - RPA464Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Mineralocorticoid Receptor (MR) - RPA464Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Mineralocorticoid Receptor (MR) - RPA464Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Mineralocorticoid receptor(NR3C2) ,partial - CSB-YP016061HU CSB-EP016061HU CSB-BP016061HU CSB-MP016061HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MCR (1-300) - sc-4419 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

Mineralocorticoid Receptor Protein (Recombinant) - abx167147 from Abbexa Category Protein Source Human Species Human

NR3C2 Peptide, Human - M34GP10601H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Mineralocorticoid Receptor (MR) - RPU54156 from Biomatik Category Protein Prices $207.00, $404.00, $647.00, $770.80 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

NR3C2 Recombinant Protein (OPCD05389) - OPCD05389 from Aviva Systems Biology Category Protein Source E.coli Species Human

Mineralocorticoid R/NR3C2 Recombinant Protein Antigen - NBP2-57853PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Mineralocorticoid Receptor, Recombinant Protein - MBS2030293 from MyBioSource Category Protein Prices $195.00, $420.00, $650.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

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