NR3C2

Gene Symbol	NR3C2
Entrez Gene	4306
Alt Symbol	MCR, MLR, MR, NR3C2VIT
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 3, group C, member 2
Other Description	aldosterone receptor|mineralocorticoid receptor|mineralocorticoid receptor 1|mineralocorticoid receptor delta
Swissprots	B0ZBF5 B0ZBF7 Q96KQ9 P08235 Q2NKL1 Q96KQ8
Accessions	AAY41033 ACA05923 ACA05924 ACA05926 ACS13715 ACS13716 ACS13718 EAX05008 P08235 AB209056 BAD92293 AJ315514 CAC67405 AJ315515 CAC67406 AK123047 AK304318 BAG65170 BC111758 AAI11759 BQ184536 DB061545 DB232659 M16801 AAA59571 XM_011531975 XP_011530277 XM_011531976 XP_011530278 XM_011531977 XP_011530279 XM_011531978 XP_011530280 NM_000901 NP_000892 NM_001166104 NP_001159576
Function	Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. {ECO:0000269|PubMed:3037703}.
Subcellular Location	Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
Tissue Specificity	Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes. {ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:9141514}.
Top Pathways	Aldosterone-regulated sodium reabsorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MCR (H-300) - sc-11412 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

MCR (C-19) - sc-6861 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MCR (N-17) - sc-6860 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MCR (H10E4C9F) - sc-53000 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

MCR (4i342) - sc-71554 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-Mineralocorticoid Receptor antibody - ab64457 from Abcam Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor antibody [H3122] - ab41912 from Abcam Prices $401.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone H3122

Anti-Mineralocorticoid Receptor antibody - N-terminal - ab174858 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody - LS-C25629 from LifeSpan Bioscience Prices $495.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-Mineralocorticoid Receptor Antibody (aa654-683, AP) - LS-C264736 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody (aa654-683, Biotin) - LS-C264739 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody (aa654-683, APC) - LS-C264738 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody (aa654-683, FITC) - LS-C264740 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody (aa654-683, PE) - LS-C264741 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody (aa654-683, Azide-free, HRP) - LS-C264742 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody - LS-C332476 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody (aa653-683) - LS-C323443 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody (N-Terminus) - LS-C107485 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody (C-Terminus) - LS-C112346 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody (clone 2B5) - LS-C197690 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2B5

Anti-Mineralocorticoid Receptor Antibody (aa1-670, clone 385707) - LS-C150007 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 385707

Anti-Mineralocorticoid Receptor Antibody (aa966-984) - LS-C312750 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody (aa654-683) - LS-C158423 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody (aa739-984) - LS-C314517 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Mineralocorticoid Receptor Antibody (aa651-700) - LS-C40521 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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