PRKDC

Gene Symbol	PRKDC
Entrez Gene	5591
Alt Symbol	DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, IMD26, XRCC7, p350
Species	Human
Gene Type	protein-coding
Description	protein kinase, DNA-activated, catalytic polypeptide
Other Description	DNA-PK catalytic subunit|DNA-dependent protein kinase catalytic subunit|hyper-radiosensitivity of murine scid mutation, complementing 1|p460
Swissprots	Q9UME3 Q7Z611 Q13327 Q59H99 Q96SE6 P78528 Q14175 P78527 Q13337
Accessions	AAA79244 AAB51722 AAC52019 AAK40350 AAP69525 BAB79635 EAW86680 EAW86681 EAW86682 EAW86683 P78527 AB208860 BAD92097 AK296833 BAG59403 BC017494 BC024963 BC037968 U34994 AAC50210 U35835 AAA79184 U47077 AAB39925 XM_011517567 XP_011515869 XM_011517568 XP_011515870 NM_001081640 NP_001075109 NM_006904 NP_008835
Function	Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylat
Subcellular Location	Nucleus. Nucleus, nucleolus.
Top Pathways	Cell cycle, Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DNA PKcs (phospho S2056) peptide - ab20406 from Abcam Category Peptide Species Human

Human DNA PKcs peptide - ab20407 from Abcam Category Peptide

Human DNA PKcs peptide - ab41959 from Abcam Category Peptide

Human DNA PKcs protein fragment - ab114159 from Abcam Category Protein Source Wheat germ Species Human

PRKDC / DNA-PKcs Antibody Blocking Peptide - LS-E7398 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DNA-PKcs Protein - H00005591-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DNA-PKcs Peptide - P1617 from Novus Biologicals Category Peptide Species Human

Phospho-DNA-PKT2609-Antibody-Blocking-peptide - BP3484a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Biotinylated-DNA-PK-T2647-Non-phospho-Control-Peptide - SP2045d from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

DNA-PK-T2647-Non-phospho-Control-Peptide - SP2045c from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Biotinylated-DNA-PK-T2647-Phospho-Peptide - SP2045b from Abgent, a WuXi AppTec company Category Peptide Prices $300.00 Sizes 1 mg

DNA-PK-T2647-Phospho-Peptide - SP2045a from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

Biotinylated-DNA-PK-T2638-Non-phospho-Control-Peptide - SP2044d from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

DNA-PK-T2638-Non-phospho-Control-Peptide - SP2044c from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Biotinylated-DNA-PK-T2638-Phospho-Peptide - SP2044b from Abgent, a WuXi AppTec company Category Peptide Prices $300.00 Sizes 1 mg

DNA-PK-T2638-Phospho-Peptide - SP2044a from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

Biotinylated-DNA-PK-S2612-Non-phospho-Control-Peptide - SP2043d from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

DNA-PK-S2612-Non-phospho-Control-Peptide - SP2043c from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Biotinylated-DNA-PK-S2612-Phospho-Peptide - SP2043b from Abgent, a WuXi AppTec company Category Peptide Prices $300.00 Sizes 1 mg

DNA-PK-S2612-Phospho-Peptide - SP2043a from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

DNA-PKcs Blocking Peptide - abx063136 from Abbexa Category Peptide Species Human, Mouse

DNA-PKcs / PRKDC / XRCC7 - H00005591-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DNA-PKcs / PRKDC / XRCC7 - H00005591-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DNA PKcs (Phospho-Thr2609) Antibody Blocking Peptide - GWB-FB362A from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

Recombinant Human PRKDC - PRKDC-28357TH from Creative Biomart Category Protein Source Wheat germ

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