PTPMT1
| Gene Symbol | PTPMT1 |
|---|---|
| Entrez Gene | 114971 |
| Alt Symbol | DUSP23, MOSP, PLIP, PNAS-129 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, mitochondrial 1 |
| Other Description | NB4 apoptosis/differentiation related protein|PTEN-like phosphatase|phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1|phosphoinositide lipid phosphatase|protein-tyrosine phosphatase mitochondrial 1 |
| Swissprots | E9PAT8 Q96CR2 Q7Z557 Q9BXV8 Q8WUK0 |
| Accessions | EAW67905 Q8WUK0 AF277187 AAK07545 AK294640 BAG57819 AY333987 AAP94732 BC014048 AAH14048 BC018974 BC020242 AAH20242 BC073798 BC107573 BM702054 BM750411 BQ050653 DA476984 DR004030 EU831440 ACE87127 EU831532 ACE86451 HQ447910 ADQ32394 NM_001143984 NP_001137456 NM_175732 NP_783859 |
| Function | Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). {ECO:0000250}. |
| Subcellular Location | Mitochondrion inner membrane {ECO:0000250}. Note=Associated with the inner membrane. {ECO:0000250}. |
PTPMT1 CRISPR/Cas9 KO Plasmid (h) - sc-403905 from Santa Cruz Biotechnology
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PTPMT1 HDR Plasmid (h) - sc-403905-HDR from Santa Cruz Biotechnology
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PTPMT1 Double Nickase Plasmid (h) - sc-403905-NIC from Santa Cruz Biotechnology
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PTPMT1 Double Nickase Plasmid (h2) - sc-403905-NIC-2 from Santa Cruz Biotechnology
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PTPMT1 CRISPR Activation Plasmid (h) - sc-403905-ACT from Santa Cruz Biotechnology
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PTPMT1 CRISPR Activation Plasmid (h2) - sc-403905-ACT-2 from Santa Cruz Biotechnology
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PTPMT1 Lentiviral Activation Particles (h) - sc-403905-LAC from Santa Cruz Biotechnology
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PTPMT1 Lentiviral Activation Particles (h2) - sc-403905-LAC-2 from Santa Cruz Biotechnology
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PTPMT1 siRNA (h) - sc-62906 from Santa Cruz Biotechnology
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PTPMT1 shRNA Plasmid (h) - sc-62906-SH from Santa Cruz Biotechnology
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PTPMT1 shRNA (h) Lentiviral Particles - sc-62906-V from Santa Cruz Biotechnology
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DUSP23 RNAi - H00054935-R01 from Novus Biologicals
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MISSION® esiRNA - EHU089091 from Sigma-Aldrich
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MISSION® esiRNA - EHU141491 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0722 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0723 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17695 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17695 from Sigma-Aldrich
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PTPMT1 siRNA (Human) - CRJ4420 from Cohesion Biosciences
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PTPMT1 CRISPR/Cas9 KO Plasmid (h2) - sc-403905-KO-2 from Santa Cruz Biotechnology
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PTPMT1 HDR Plasmid (h2) - sc-403905-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PTPMT1 (NM_175732.2) - SHH386408 from Creative biogene
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PTPMT1 shRNA Plasmid (Human) - CHJ4420 from Cohesion Biosciences
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PTPMT1 miRNA 3'UTR clone - MiUTR3H-10669 from Creative biogene
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