| Gene Symbol |
UBE2S
|
| Entrez Gene |
27338
|
| Alt Symbol |
E2-EPF, E2EPF, EPF5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2S
|
| Other Description |
E2-EPF5|ubiquitin carrier protein S|ubiquitin-conjugating enzyme E2 S|ubiquitin-conjugating enzyme E2-24 kD|ubiquitin-conjugating enzyme E2-24 kDa|ubiquitin-conjugating enzyme E2-EPF5|ubiquitin-protein ligase S
|
| Swissprots |
Q16763 Q9BTC1
|
| Accessions |
ABC40675 EAW72377 Q16763 AB062397 BAB93484 BC004236 AAH04236 BC007554 AAH07554 BC065364 AAH65364 BC066948 AAH66948 CA421746 CN305224 HQ448521 ADQ33000 M91670 AAA58446 XM_011526752 XP_011525054 XM_011526753 XP_011525055 NM_014501 NP_055316
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000
|
| Top Pathways |
Ubiquitin mediated proteolysis
|