UBE2S

Gene Symbol	UBE2S
Entrez Gene	27338
Alt Symbol	E2-EPF, E2EPF, EPF5
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2S
Other Description	E2-EPF5|ubiquitin carrier protein S|ubiquitin-conjugating enzyme E2 S|ubiquitin-conjugating enzyme E2-24 kD|ubiquitin-conjugating enzyme E2-24 kDa|ubiquitin-conjugating enzyme E2-EPF5|ubiquitin-protein ligase S
Swissprots	Q16763 Q9BTC1
Accessions	ABC40675 EAW72377 Q16763 AB062397 BAB93484 BC004236 AAH04236 BC007554 AAH07554 BC065364 AAH65364 BC066948 AAH66948 CA421746 CN305224 HQ448521 ADQ33000 M91670 AAA58446 XM_011526752 XP_011525054 XM_011526753 XP_011525055 NM_014501 NP_055316
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® UBE2S siRNA II - 7732 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® UBE2S siRNA I - 7220 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

UBE2S CRISPR/Cas9 KO Plasmid (h) - sc-404140 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2S HDR Plasmid (h) - sc-404140-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2S Double Nickase Plasmid (h) - sc-404140-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2S Double Nickase Plasmid (h2) - sc-404140-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2S CRISPR Activation Plasmid (h) - sc-404140-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2S CRISPR Activation Plasmid (h2) - sc-404140-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2S Lentiviral Activation Particles (h) - sc-404140-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2S Lentiviral Activation Particles (h2) - sc-404140-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

UBE2S siRNA (h) - sc-97109 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UBE2S shRNA Plasmid (h) - sc-97109-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UBE2S shRNA (h) Lentiviral Particles - sc-97109-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

UBE2S RNAi - H00027338-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU147811 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22385 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22385 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01193 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr01193

UBE2S siRNA (Human) - CRH9087 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UBE2S - MBS8204889 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human UBE2S(NM_014501.2) - SHL111618 from Creative biogene Category siRNA Species Reactivities Human

UBE2S shRNA Plasmid (Human) - CHH9087 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

UBE2S miRNA 3'UTR clone - MiUTR1H-10958 from Creative biogene Species Reactivities Human

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